COX-2/sEH-IN-1
COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks.
For research use only. We do not sell to patients.
- CAS No.: 2474977-38-1
- Formula: C23H18F3N5O3S
- Molecular Weight:501.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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sEH 0.40 nM (IC50) |
COX-2 1.24 μM (IC50) |
COX-1 8.72 μM (IC50) |
COX-2/sEH-IN-1 (50 mg/kg; p.o.; once) shows high anti-inflammatory activity[1].
COX-2/sEH-IN-1 (100 mg/kg; p.o.; 2 weeks) affords a perfect cardio-protection and less cardiovascular liabilities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino mice (20-30 g)[1]
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Dosage:10 mg/kg
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Administration:Oral administration, once
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Result:Exhibited analgesic activity with 65.67% inhibition in the number of writhing.
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Animal Model:Albino rats (120-150 g), carrageenan-induced paw edema model[1]
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Dosage:50 mg/kg
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Administration:Oral administration, once
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Result:Showed high anti-inflammatory activity with edema inhibition of 64.06%, 95.82%, and 98.15% at 1, 3, 5 h, respectively.
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Animal Model:Adult male albino Wister rats (170-200 g)[1]
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Dosage:100 mg/kg
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Administration:Oral administration, 2 weeks
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Result:Exhibited a significant lowering in Troponine-I, LDH and CK-MB levels when compared to celecoxib treated group. Showed remarkably decrease in TNF-α concentration compared to the celecoxib induced cardio-toxicity group. Restored heart GSH level and significantly increased PGI2 level compared to celecoxib group. Showed mild decongestant and mild edema on cardiac blood vessels and showed more or less normal muscle bundles.
Chemical Information
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CAS No. 2474977-38-1
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Molecular Weight 501.48
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Formula C23H18F3N5O3S
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SMILES
NS(=O)(C1=CC=C(C=C1)N2N=C(C=C2C3=CC=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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