2474977-38-1
Chemical Structure
COX-2/sEH-IN-1
- CAS No.: 2474977-38-1
- Formula:C23H18F3N5O3S
- Molecular Weight:501.48
IUPAC Name: 4-(5-phenyl-3-(3-(4-(trifluoromethyl)phenyl)ureido)-1H-pyrazol-1-yl)benzenesulfonamide
InChIKey: ZBEQKLACMVOCMB-UHFFFAOYSA-N
SMILES: NS(=O)(C1=CC=C(C=C1)N2N=C(C=C2C3=CC=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
Biological Activity: COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks[1].
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COX-2/sEH-IN-1 | COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks. | |||||||||||||||||||||
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Keywords
