RIPK3-IN-4
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury.
For research use only. We do not sell to patients.
- CAS No.: 2304617-58-9
- Formula: C24H18BrFN4O3S
- Molecular Weight:541.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | CC50 |
>50 μM
Compound: 42
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Cytotoxicity against human HT-29 cells measured after 12 hrs by CellTiter-Glo Luminescent assay
Cytotoxicity against human HT-29 cells measured after 12 hrs by CellTiter-Glo Luminescent assay
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[PMID: 31095385] |
| HT-29 | EC50 |
0.44 μM
Compound: 42
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Anti-necroptotic activity in human HT-29 cells assessed as inhibition of NFalpha/SM-164/Z-VAD-fmk-induced necroptosis measured after 12 hrs by celltiter-glo luminescent cell viability assay
Anti-necroptotic activity in human HT-29 cells assessed as inhibition of NFalpha/SM-164/Z-VAD-fmk-induced necroptosis measured after 12 hrs by celltiter-glo luminescent cell viability assay
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[PMID: 31095385] |
Chemical Information
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CAS No. 2304617-58-9
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Molecular Weight 541.39
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Formula C24H18BrFN4O3S
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SMILES
O=C(NC1=NC(C=CC(OC2=CC=C(F)C(NC(NC3=CC(Br)=CC=C3)=O)=C2)=C4)=C4S1)C5CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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