6,4'-Dihydroxy-7-methoxyflavanone
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 189689-32-5
- Fòrmula: C16H14O5
- Peso molecular:286.28
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>100 μM
Compound: 14
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
|
[PMID: 23743282] |
In Vitro
6,4'-Dihydroxy-7-methoxyflavanone (3-30 µM; macrophages) inhibits osteoclastogenesis and TRAP activity in a dose-dependent manner[1].
6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM; 48 h) disrupts actin ring formation of mature osteoclasts[1].
6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM; 1 h; macrophages) inhibits RANKL-induced expression of nuclear factor of activatied T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) and c-Fos via inhibition of mitogen activated protein kinases (MAPKs) pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Macrophages
-
Concentration:0, 1, 3, 10, and 30 µM
-
Incubation Time:1 hours
-
Result:Inhibited RANKL-induced phosphorylation of JNK without decrease of the phosphorylation of ERK and p38 MAPK.
Chemical Information
-
No. CAS 189689-32-5
-
Peso molecular 286.28
-
Fòrmula C16H14O5
-
SMILES
O=C1C2=CC(O)=C(OC)C=C2O[C@H](C3=CC=C(C=C3)O)C1
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6,4'-Dihydroxy-7-methoxyflavanone Related Classifications
HY-N9736 Related Classifications
Powered by Bioz