2. Neuronal Signaling
  3. Calcineurin
  4. 6,4'-Dihydroxy-7-methoxyflavanone

6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.

For research use only. We do not sell to patients.

6,4'-Dihydroxy-7-methoxyflavanone Chemical Structure

6,4'-Dihydroxy-7-methoxyflavanone Chemical Structure

CAS No. : 189689-32-5

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6,4'-Dihydroxy-7-methoxyflavanone Related Antibodies

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Description

6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis[1].

In Vitro

6,4'-Dihydroxy-7-methoxyflavanone (3-30 µM; macrophages) inhibits osteoclastogenesis and TRAP activity in a dose-dependent manner[1].
6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM; 48 h) disrupts actin ring formation of mature osteoclasts[1].
6,4'-Dihydroxy-7-methoxyflavanone (0-30 µM; 1 h; macrophages) inhibits RANKL-induced expression of nuclear factor of activatied T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) and c-Fos via inhibition of mitogen activated protein kinases (MAPKs) pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6,4'-Dihydroxy-7-methoxyflavanone Related Antibodies

Western Blot Analysis[1]

Cell Line: Macrophages
Concentration: 0, 1, 3, 10, and 30 µM
Incubation Time: 1 hours
Result: Inhibited RANKL-induced phosphorylation of JNK without decrease of the phosphorylation of ERK and p38 MAPK.
Molecular Weight

286.28

Formula

C16H14O5
CAS No.
SMILES

O=C1C2=CC(O)=C(OC)C=C2O[C@H](C3=CC=C(C=C3)O)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6,4'-Dihydroxy-7-methoxyflavanone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,4'-Dihydroxy-7-methoxyflavanone189689-32-5CalcineurinPP2BPPP3flavonoidnature productDalbergia odoriferaosteoclastogenesisantioxidantanti-inflammatoryneuroprotectiveInhibitorinhibitorinhibit

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