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Cat. No.: HY-N8936

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Narchinol B

Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

For research use only. We do not sell to patients.

CAS No.: 1356822-09-7
Formula: C₁₂H₁₆O₃
Molecular Weight:208.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Narchinol B Chemical Structure

CAS No.: 1356822-09-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	1.7 μM Compound: 4	Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced TNFalpha production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
BV-2	IC₅₀	1.73 μM Compound: 4	Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL-1beta production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
BV-2	IC₅₀	2.38 μM Compound: 4	Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs Inhibition of lipopolysaccharide-induced PGE2 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs	[PMID: 29221883]
BV-2	IC₅₀	2.43 μM Compound: 4	Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA Inhibition of lipopolysaccharide-induced nitric oxide production in mouse BV2 cells assessed as reduction in nitrite level by Griess reaction based ELISA	[PMID: 29221883]
BV-2	IC₅₀	2.9 μM Compound: 4	Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL6 production in mouse BV2 cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	3.1 μM Compound: 4	Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs Inhibition of lipopolysaccharide-induced PGE2 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs	[PMID: 29221883]
Microglia	IC₅₀	3.11 μM Compound: 4	Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL-1beta production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	4 μM Compound: 4	Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced IL6 production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
Microglia	IC₅₀	4.17 μM Compound: 4	Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA Inhibition of lipopolysaccharide-induced nitric oxide production in Sprague-Dawley rat primary microglia cells assessed as reduction in nitrite level by Griess reaction based ELISA	[PMID: 29221883]
Microglia	IC₅₀	9.83 μM Compound: 4	Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA Inhibition of lipopolysaccharide-induced TNFalpha production in in Sprague-Dawley rat primary microglia cells pre-incubated for 1 hr before LPS stimulation for 24 hrs by ELISA	[PMID: 29221883]
RAW264.7	IC₅₀	4.6 μM Compound: 8	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 22079762]

Chemical Information

CAS No. 1356822-09-7
Molecular Weight 208.25
Formula C₁₂H₁₆O₃
SMILES

C[C@@]([C@@H](C1)C)([C@@H](C=C2)O)C(C2=O)=C[C@H]1O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoon CS, et al. Anti-neuroinflammatory effects of sesquiterpenoids isolated from Nardostachys jatamansi. Bioorg Med Chem Lett. 2018 Jan 15;28(2):140-144. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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