1. Immunology/Inflammation
  2. COX
  3. Ampiroxicam

Ampiroxicam (Synonyms: CP 65703)

Cat. No.: HY-17484 Purity: 97.12%
Handling Instructions

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

For research use only. We do not sell to patients.

Ampiroxicam Chemical Structure

Ampiroxicam Chemical Structure

CAS No. : 99464-64-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 78 In-stock
Estimated Time of Arrival: December 31
10 mg USD 71 In-stock
Estimated Time of Arrival: December 31
50 mg USD 184 In-stock
Estimated Time of Arrival: December 31
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Description

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Target: COX Ampiroxicam is a non-steroidal anti-inflammatory drug. It is a prodrug of piroxicam. Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats [1]. Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam [2].

IC50 & Target

COX

 

Molecular Weight

447.46

Formula

C₂₀H₂₁N₃O₇S

CAS No.

99464-64-9

SMILES

O=C(OC(OC(C1=CC=CC=C12)=C(C(NC3=NC=CC=C3)=O)N(C)S2(=O)=O)C)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2348 mL 11.1742 mL 22.3484 mL
5 mM 0.4470 mL 2.2348 mL 4.4697 mL
10 mM 0.2235 mL 1.1174 mL 2.2348 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AmpiroxicamCP 65703CP65703CP-65703COXCyclooxygenaseInhibitorinhibitorinhibit

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Product name:
Ampiroxicam
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HY-17484
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