2. Immunology/Inflammation PROTAC
  3. STING PROTACs
  4. PROTAC STING Degrader-1

PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity.

For research use only. We do not sell to patients.

PROTAC STING Degrader-1 Chemical Structure

PROTAC STING Degrader-1 Chemical Structure

CAS No. : 2762552-74-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 682 In-stock
Solution
10 mM * 1 mL in DMSO USD 682 In-stock
Solid
1 mg USD 220 In-stock
5 mg USD 620 In-stock
10 mg USD 980 In-stock
25 mg USD 1950 In-stock
50 mg USD 3250 In-stock
100 mg USD 5200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

PROTAC STING Degrader-1 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity[1].

Molecular Weight

699.67

Formula

C34H33N7O10
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)/C=C/C(NC4=CC=C(NC(C5=CC=C([N+]([O-])=O)O5)=O)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (142.92 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4292 mL 7.1462 mL 14.2925 mL
5 mM 0.2858 mL 1.4292 mL 2.8585 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4292 mL 7.1462 mL 14.2925 mL 35.7311 mL
5 mM 0.2858 mL 1.4292 mL 2.8585 mL 7.1462 mL
10 mM 0.1429 mL 0.7146 mL 1.4292 mL 3.5731 mL
15 mM 0.0953 mL 0.4764 mL 0.9528 mL 2.3821 mL
20 mM 0.0715 mL 0.3573 mL 0.7146 mL 1.7866 mL
25 mM 0.0572 mL 0.2858 mL 0.5717 mL 1.4292 mL
30 mM 0.0476 mL 0.2382 mL 0.4764 mL 1.1910 mL
40 mM 0.0357 mL 0.1787 mL 0.3573 mL 0.8933 mL
50 mM 0.0286 mL 0.1429 mL 0.2858 mL 0.7146 mL
60 mM 0.0238 mL 0.1191 mL 0.2382 mL 0.5955 mL
80 mM 0.0179 mL 0.0893 mL 0.1787 mL 0.4466 mL
100 mM 0.0143 mL 0.0715 mL 0.1429 mL 0.3573 mL
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PROTAC STING Degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC STING Degrader-12762552-74-7PROTAC STING Degrader1PROTAC STING Degrader 1STINGPROTACsStimulator of Interferon GenesTMEM173MITAERISMPYSanti-inflammatorystimulator of interferon genesInhibitorinhibitorinhibit

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