2762552-74-7
2762552-74-7
Chemical Structure
PROTAC STING Degrader-1
- CAS No.: 2762552-74-7
- Formula:C34H33N7O10
- Molecular Weight:699.67
IUPAC Name: sodium tetrahydroborate-d4
InChIKey: TXNQXRGOKABDOB-FOCLMDBBSA-N
SMILES: O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)/C=C/C(NC4=CC=C(NC(C5=CC=C([N+]([O-])=O)O5)=O)C=C4)=O
Biological Activity: PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. PROTAC STING Degrader-1 exerts high anti-inflammatory efficacy. PROTAC STING Degrader-1 can be used to study diseases such as acute kidney injury and inflammatory bowel diseases (IBDs)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC STING Degrader-1 | 98.26% | PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. PROTAC STING Degrader-1 exerts high anti-inflammatory efficacy. PROTAC STING Degrader-1 can be used to study diseases such as acute kidney injury and inflammatory bowel diseases (IBDs). | ||||||||||||||||||||
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References
- [1]. Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611. [Content Brief]
- [2]. Rongxiang Ma, et al., Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury, European Journal of Medicinal Chemistry, Volume 290, 2025, 117539, ISSN 0223-5234. [Content Brief]
- [3]. Shuai Xu, et al., PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis, International Immunopharmacology, Volume 141, 2024, 112990, ISSN 1567-5769. [Content Brief]
Keywords
