2. Immunology/Inflammation Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt Apoptosis
  3. Interleukin Related JAK STAT Caspase Bcl-2 Family
  4. Fezakinumab

Fezakinumab  (Synonyms: ILV 094)

Cat. No.: HY-P99244 Purity: 99.9%
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Fezakinumab (ILV 094) is an anti-IL-22 monoclonal antibody. Fezakinumab inhibits IL-22 signal transduction, and regulates the JAK1/STAT3 pathway as well as apoptotic proteins. Fezakinumab alleviates airway remodeling, alveolar enlargement and inflammatory cell infiltration in lung tissues. Fezakinumab reduces the levels of neutrophils, lymphocytes, eosinophils and macrophages in lung tissues. Fezakinumab can be used in the research of chronic obstructive pulmonary disease and skin diseases.

For research use only. We do not sell to patients.

CAS No. : 1007106-86-6

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Description

Fezakinumab (ILV 094) is an anti-IL-22 monoclonal antibody. Fezakinumab inhibits IL-22 signal transduction, and regulates the JAK1/STAT3 pathway as well as apoptotic proteins. Fezakinumab alleviates airway remodeling, alveolar enlargement and inflammatory cell infiltration in lung tissues. Fezakinumab reduces the levels of neutrophils, lymphocytes, eosinophils and macrophages in lung tissues. Fezakinumab can be used in the research of chronic obstructive pulmonary disease and skin diseases[1].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

IL-22

 

JAK1

 

STAT3

 

Caspase 3

 

Bcl-2

 

In Vivo

Fezakinumab (5 mg/kg; i.p.; once daily; 8 weeks) significantly reduces BALF T-22 cell and IL-22 levels, improves lung histopathology, and modulates JAK1/STAT3 pathway and apoptosis-related proteins to alleviate cigarette smoke-induced COPD in male C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 8-10 weeks old, 18-22 g, cigarette smoke-induced COPD model)[1]
Dosage: 5 mg/kg
Administration: i.p.; once daily; 8 weeks
Result: Reduced T-22 cell levels in BALF.
Reduced IL-22 levels in BALF.
Reduced average alveolar intercept.
Increased alveolar count.
Lowered lung tissue inflammatory cell infiltration (neutrophils, lymphocytes, eosinophils, macrophages).
Reduced IL-22R1 expression in lung tissue.
Reduced lung tissue levels of JAK1, p-STAT3, Caspase3, and STAT3.
Increased lung tissue levels of Bcl-2.
Showed no significant difference in Bax and TYK2 levels compared to the CS group.
Improved lung architecture, with more uniform alveolar size, reduced airway epithelial proliferation, minimal interstitial thickening, and markedly reduced inflammatory cell infiltration.
Clinical Trial
Gene ID

50616  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.84 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Fezakinumab]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized IL-22 Protein, Human (HY-P7039) can bind Fezakinumab. The EC50 for this effect is 41.06 ng/mL.
Purity & Documentation
References
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Fezakinumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fezakinumab1007106-86-6ILV 094ILV094ILV-094Interleukin RelatedJAKSTATCaspaseBcl-2 FamilyILJanus kinasechronic obstructive pulmonary diseaseCaspase3IL-22JAK1/STAT3 pathwayBcl-2C57BL/6 miceIL-22R1T-22 celllung tissuebronchoalveolar lavage fluidInhibitorinhibitorinhibit

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