IL22 - interleukin 22 Gene

Also Known as TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50616

About IL22

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,248,242-68,253,604 (from NCBI)

This gene has 2 transcripts (splice variants) and 121 orthologues. Low expression observed in reference dataset.

Summary

This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]

IL22 Products (1)

mRNA	Protein	Name
NM_020525.5	NP_065386.1	interleukin-22 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12513909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL22 Protein Structure

IL22

0
100
179 a.a.

Protein Preferred Names	Protein Names
interleukin-22	IL-10-related T-cell-derived inducible factor

IL22 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL22	Q9GZX6	IL10RB	Homo sapiens	Q08334	SPR	20462497
Intra	IL22	Q9GZX6	IL10RB	Homo sapiens	Q08334	SPR	12513909
Intra	IL22	Q9GZX6	IL22RA1	Homo sapiens	Q8N6P7	X-Ray Diffraction	18599299
Intra	IL22	Q9GZX6	IL22RA1	Homo sapiens	Q8N6P7	SPR	20462497
Intra	IL22	Q9GZX6	IL22RA1	Homo sapiens	Q8N6P7	SPR	12513909
Intra	IL22	Q9GZX6	IL22RA1	Homo sapiens	Q8N6P7	SPR	18599299

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL22 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7039	IL-22 Protein, Human	Q9GZX6 (A34-I179)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7039A	IL-22 Protein, Human (HEK293)	Q9GZX6 (A34-I179)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73192	IL-22 Protein, Human (P.pastoris, His)	Q9GZX6 (A34-I179)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78857	IL-22 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9GZX6 (A34-I179)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P7039C	IL-22 Protein, Human (His)	Q9GZX6 (A34-I179)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700113AF	Animal-Free IL-22 Protein, Human (His)	Q9GZX6 (A34-I179)	≥ 95%, as determined by reducing SDS-PAGE.

IL22 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84784	IL22 Antibody (YA4481)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84784A	IL22 Antibody (YA4481)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Scleritis
Acute Generalized Exanthematous Pustulosis	Agep Pustular Drug Eruption Toxic Pustuloderma
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Psoriasis
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease 23	IBD23
Colitis
Erythematosquamous Dermatosis	Other Erythematosquamous Dermatosis
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Inflammatory Bowel Disease 24	IBD24
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Autoimmune Disease Of Skin And Connective Tissue
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99244	Fezakinumab		99.9%	Phase 2
HY-P99919	Efmarodocokin alfa	Activator	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147128	PY109	Agonist	99.15%	Unkown
HY-133552	RORγt Inverse agonist 10	Antagonist	99.13%	Unkown
HY-RS06737	IL22RA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-168971	Paeoniflorin-6′-O-benzene sulfonate		/	Unkown
HY-182795	Colchicine derivative-1		/	Unkown
HY-184385	PI3K/AKT/JAK2-IN-1	Inhibitor	/	Unkown
HY-RS06736	IL22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06738	IL22RA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174618	Human IL22RA2 mRNA		/	Unkown
HY-174619	Human IL22RA1 mRNA		/	Unkown
HY-174620	Human IL22 mRNA		/	Unkown
HY-RS16854	Il22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21241	Il22ra1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23295	Il22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27758	Il22ra1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990016	Temtokibart	Inhibitor	99.23%	Unkown
HY-P99917	Eflepedocokin alfa	Activator	≥99.0%	Unkown
HY-P990735	Donzakimig		98.67%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL22	VGNC	VGNC:41969
Felis catus	IL22	VGNC	VGNC:84037
Bos taurus	IL22	VGNC	VGNC:30143
Rattus norvegicus	IL22	RGD	RGD:1561292
Macaca mulatta	IL22	VGNC	VGNC:99944
Others	IL22	NCBI