IL22 Antibody (YA4481)
(Synonyms: TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23)IL22 Antibody (YA4481) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL22.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
IL22 Antibody (YA4481) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL22.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 20 kDa
Purified recombinant fragment of human IL22 (AA: 34-179) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-22 is a member of the IL-10 cytokine family that primarily mediates communication between immune cells and epithelial tissues[1][2]. Produced by multiple leukocyte subsets, including Th17, Th22, γδ T cells, and innate lymphoid cells, IL-22 signals through a heterodimeric receptor complex expressed mainly on non-hematopoietic cells[2][3][4]. Mechanistically, IL-22 activates the STAT3 pathway in epithelial cells, promoting anti-apoptotic, pro-proliferative, and tissue-regenerative responses[1][3]. In the gastrointestinal tract, IL-22 enhances epithelial barrier function by stimulating mucus secretion, antimicrobial peptide production, and epithelial cell proliferation, which contributes to protection against infections and supports tissue repair[5][6][7]. Compared with IL-17, IL-22 exerts more regenerative and protective effects rather than pro-inflammatory responses in epithelial tissues[8]. Dysregulation of IL-22 has been implicated in autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, where aberrant signaling can exacerbate tissue pathology[9][6]. In experimental models, IL-22 administration promotes tissue repair in lung injury, pancreatitis, and liver damage, while receptor-specific antagonists allow precise modulation of IL-22-driven responses[1][10][11]. Therapeutic strategies targeting IL-22, including recombinant cytokines and IL-22 binding protein modulation, are being explored for chronic inflammatory disorders and gastrointestinal acute graft-versus-host disease[2][12][11].
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Subcellular Localization
Secreted
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SwissProt ID
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Synonyms
TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Documentation
References
[1]. Zenewicz LA. IL-22: There Is a Gap in Our Knowledge. Immunohorizons. 2018 Jul 5;2(6):198-207. doi: 10.4049/immunohorizons.1800006. PMID: 31022687; PMCID: PMC10518850. et al. IL-22: There Is a Gap in Our Knowledge. Immunohorizons. 2018 Jul 5;2(6):198-207. [Content Brief]
[2]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]
[3]. Mühl H, et al. IL-22 in tissue-protective therapy. Br J Pharmacol. 2013 Jun;169(4):761-71. [Content Brief]
[4]. Mühl H, et al. IL-18/IL-18BP and IL-22/IL-22BP: Two interrelated couples with therapeutic potential. Cell Signal. 2019 Nov;63:109388. [Content Brief]
[5]. Zenewicz LA, et al. Recent advances in IL-22 biology. Int Immunol. 2011 Mar;23(3):159-63. [Content Brief]
[6]. Ulu A, et al. IL-22 regulates inflammatory responses to agricultural dust-induced airway inflammation. Toxicol Appl Pharmacol. 2022 Jul 1;446:116044. [Content Brief]
[7]. Mohty M, et al. IL-22, a new beacon in gastrointestinal aGVHD. Blood. 2023 Mar 23;141(12):1369-1370. [Content Brief]
[8]. Liang SC, et al. IL-22 induces an acute-phase response. J Immunol. 2010 Nov 1;185(9):5531-8. [Content Brief]
[9]. Dean LS, et al. I don't know about you, but I'm feeling IL-22. Cytokine Growth Factor Rev. 2024 Dec;80:1-11. [Content Brief]
[10]. Li J, et al. IL-22, a vital cytokine in autoimmune diseases. Clin Exp Immunol. 2024 Nov 12;218(3):242-263. [Content Brief]
[11]. Keir M, et al. The role of IL-22 in intestinal health and disease. J Exp Med. 2020 Feb 13;217(3):e20192195. [Content Brief]
[12]. Eyerich S, et al. IL-17 and IL-22: siblings, not twins. Trends Immunol. 2010 Sep;31(9):354-61. [Content Brief]
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