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Donzakimig

(Synonyms: UCB-1381)
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Based on 1 Customer Validation

Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions.

For research use only. We do not sell to patients.

  • Purity: 98.67%
  • CAS No.: 2765066-99-5
  • Molecular Weight:101.048 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Donzakimig
  • Experimental Validation Results for Donzakimig
  • Experimental Validation Results for Donzakimig
  • Experimental Validation Results for Donzakimig
  • Donzakimig Chemical Structure
    Donzakimig Chemical Structure
CAS No.: 2765066-99-5
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Fab-G1_kappa-scFv-heavy-kappa

  • 1/16

    Immobilized Human IL-22 Protein, His Tag can bind Donzakimig. The EC50 for this effect is 232 ng/mL.

  • 1/16

    Immobilized Human ALB-His-Q Tag can bind Donzakimig. The EC50 for this effect is 145.8 ng/mL.

  • 1/16

    Immobilized Human IL-13 Protein, His Tag can bind Donzakimig. The EC50 for this effect is 287.2 ng/mL.

  • Donzakimig Chemical Structure
    1/16
  • Donzakimig
  • Immobilized Human IL-22 Protein, His Tag can bind Donzakimig. The EC50 for this effect is 232 ng/mL.
  • Immobilized Human ALB-His-Q Tag can bind Donzakimig. The EC50 for this effect is 145.8 ng/mL.
  • Immobilized Human IL-13 Protein, His Tag can bind Donzakimig. The EC50 for this effect is 287.2 ng/mL.
  • Fab-G1_kappa-scFv-heavy-kappa