MLN3126
Based on 1 Customer Validation
MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx.
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 628300-71-0
- Formula: C21H19ClN2O5S
- Molecular Weight:446.90
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MLN3126 inhibits CCL25-induced calcium mobilization with an IC50 value of 6.3 nM in CCR9 expressing cells[1].
MLN3126 inhibits the binding of biotinylated CCL25 to CCR9 with an IC50 of 14.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse thymocytes
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Concentration:0.01, 0.03, 0.1, 0.3, 1, 3 μM
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Incubation Time:90 min
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Result:Inhibited CCL25-induced chemotaxis of mouse thymocytes.
MLN3126 (0.05, 0.25 and 1% (w/w); p.o.) has the potential activity for alleviating inflammatory bowel disease (IBD)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Activated T cell transferred colitis mouse model[1]
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Dosage:0.05, 0.25 and 1% (w/w) (around 4 g/day)
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Administration:Oral gavage; 21 days
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Result:Blocked CCR9/CCL25 interaction by inhibiting migration of T cells to the colon and resulted in the amelioration of colitis.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 628300-71-0
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Appearance Solid
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Molecular Weight 446.90
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Formula C21H19ClN2O5S
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Color White to off-white
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SMILES
O=S(C1=CC=C(OC(C)C)C=C1)(NC2=CC=C(Cl)C=C2C(C3=CC=[N+]([O-])C=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2376 mL | 11.1882 mL | 22.3764 mL | 55.9409 mL |
| 5 mM | 0.4475 mL | 2.2376 mL | 4.4753 mL | 11.1882 mL | |
| 10 mM | 0.2238 mL | 1.1188 mL | 2.2376 mL | 5.5941 mL | |
| 15 mM | 0.1492 mL | 0.7459 mL | 1.4918 mL | 3.7294 mL | |
| 20 mM | 0.1119 mL | 0.5594 mL | 1.1188 mL | 2.7970 mL | |
| 25 mM | 0.0895 mL | 0.4475 mL | 0.8951 mL | 2.2376 mL | |
| 30 mM | 0.0746 mL | 0.3729 mL | 0.7459 mL | 1.8647 mL | |
| 40 mM | 0.0559 mL | 0.2797 mL | 0.5594 mL | 1.3985 mL | |
| 50 mM | 0.0448 mL | 0.2238 mL | 0.4475 mL | 1.1188 mL |
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