2. Immunology/Inflammation
  3. Kallikrein
  4. Donidalorsen sodium

Donidalorsen sodium  (Synonyms: ISIS-721744; IONIS-PKK-LRX)

Cat. No.: HY-139787A Purity: 95.90%
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Donidalorsen (ISIS-721744; IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema.

For research use only. We do not sell to patients.

DNA, d([2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]rG-sp-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-sp-G-sp-T-sp-m5C-sp-T-sp-m5C-sp-T-sp-T-sp-G-sp-G-sp-m5C-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rA-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)

Donidalorsen sodium Chemical Structure

CAS No. : 2304701-45-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Donidalorsen sodium:

Donidalorsen sodium Related Antibodies

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KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

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Description

Donidalorsen (ISIS-721744; IONIS-PKK-LRX) sodium is an antisense oligonucleotide targeting prekallikrein (PKK). Donidalorsen sodium inhibits kallikrein activity and reduces the production of Bradykinin (HY-P0206) by specifically binding to and degrading PKK mRNA in the liver. Donidalorsen sodium can be used in the research of hereditary angioedema[1][2].

In Vitro

Donidalorsen sodium binds selectively to hepatic prekallikrein mRNA, mediates its degradation via ribonuclease H1, reduces hepatic prekallikrein production, reduces plasma prekallikrein concentrations, reduces plasma D-dimer concentrations, inhibits prekallikrein protein production, and reduces hereditary angioedema attack frequency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Donidalorsen sodium Related Antibodies
Molecular Weight

8672.6 (free acid)

Formula

C296H435N83Na20O151P20S15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Donidalorsen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Donidalorsen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Donidalorsen2304701-45-7ISIS-721744 IONIS-PKK-LRXISIS721744ISIS 721744KallikreinKLKKallikrein-related peptidasehepatocyte asialoglycoprotein receptorsprekallikrein proteintriantennary N-acetylgalactosamineprekallikrein mRNAplasma prekallikreinhereditary angioedemaribonuclease H1bradykininexon 9HAE type I or IIInhibitorinhibitorinhibit

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