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Cat. No.: HY-149961

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Anti-inflammatory agent 40

Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

For research use only. We do not sell to patients.

CAS No.: 3043821-37-7
Formula: C₃₀H₂₄Cl₂N₂O₄
Molecular Weight:547.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Anti-inflammatory agent 40 Chemical Structure

CAS No.: 3043821-37-7

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

All Parasite Isoforms :

In Vitro

Anti-inflammatory agent 40 (compound 5p) is against both CQ-sensitive and resistant strains of P. falciparum, Anti-inflammatory agent 40 exhibits IC₅₀ value 1.47 μM against chloroquine sensitive strain of P. falciparum (Pf3D7)^[1].
Anti-inflammatory agent 40 inhibits LPS induced MAP kinase activation and decreases pERK1/2 (Thr202/Tyr204) and pJNK1/2 expression in THP-1 monocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-inflammatory agent 40 (compound 5p) (p.o, 1 h prior to caraageenan injection；25, 50 and 100 mg/kg；Paw swelling was subsequently monitored after 4 and 6) shows inhibition in swiss mice, the Carrageenan inhibition percent are 61%, 56% at 25mg/kg after 4h or 6h, respectively. the Carrageenan inhibition percent are 62%, 56% at 50 mg/kg after 4h or 6h, respectively, and 73%, 65% at 50 mg/kg after 4h or 6h, respectively ^[1].
Anti-inflammatory agent 40 exhibits good PK profile, it is satisfactory and can be attested for the candidates for future drug discovery optimization, the C_max, T_max, AUC, t_1/2 are 110.37 ± 11.92 ng/mL, 0.25 ± 0.0 h, 86.91 ± 16.86 h.ng/mL and 0.87 ± 0.15 h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3043821-37-7
Molecular Weight 547.43
Formula C₃₀H₂₄Cl₂N₂O₄
SMILES

CC1=C(C(C2=CC=C(C=C2)Cl)=C(N1CCC3=CC(OC3O)=O)C4=CC=C(C=C4)Cl)C(NC5=CC=CC=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alka Raj Pandey, et al. Design, synthesis and evaluation of novel pyrrole-hydroxybutenolide hybrids as promising antiplasmodial and anti-inflammatory agents. Eur J Med Chem. 2023 Jun 5;254:115340 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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