Anti-inflammatory agent 40 

Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

Anti-inflammatory agent 40 (compound 5p) is against both CQ-sensitive and resistant strains of P. falciparum, Anti-inflammatory agent 40 exhibits IC₅₀ value 1.47 μM against chloroquine sensitive strain of P. falciparum (Pf3D7)^[1].
Anti-inflammatory agent 40 inhibits LPS induced MAP kinase activation and decreases pERK1/2 (Thr202/Tyr204) and pJNK1/2 expression in THP-1 monocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 40 (compound 5p) (p.o, 1 h prior to caraageenan injection；25, 50 and 100 mg/kg；Paw swelling was subsequently monitored after 4 and 6) shows inhibition in swiss mice, the Carrageenan inhibition percent are 61%, 56% at 25mg/kg after 4h or 6h, respectively. the Carrageenan inhibition percent are 62%, 56% at 50 mg/kg after 4h or 6h, respectively, and 73%, 65% at 50 mg/kg after 4h or 6h, respectively ^[1].
Anti-inflammatory agent 40 exhibits good PK profile, it is satisfactory and can be attested for the candidates for future drug discovery optimization, the C_max, T_max, AUC, t_1/2 are 110.37 ± 11.92 ng/mL, 0.25 ± 0.0 h, 86.91 ± 16.86 h.ng/mL and 0.87 ± 0.15 h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

547.43

C₃₀H₂₄Cl₂N₂O₄

CC1=C(C(C2=CC=C(C=C2)Cl)=C(N1CCC3=CC(OC3O)=O)C4=CC=C(C=C4)Cl)C(NC5=CC=CC=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Alka Raj Pandey, et al. Design, synthesis and evaluation of novel pyrrole-hydroxybutenolide hybrids as promising antiplasmodial and anti-inflammatory agents. Eur J Med Chem. 2023 Jun 5;254:115340  [Content Brief]