ST-1006 Maleate
ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect.
For research use only. We do not sell to patients.
- CAS No.: 1196994-12-3
- Formula: C24H28Cl2N6O8
- Molecular Weight:599.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1]
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Dosage:1-100 mg/kg
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Administration:Subcutaneous injection
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Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
Chemical Information
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CAS No. 1196994-12-3
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Molecular Weight 599.42
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Formula C24H28Cl2N6O8
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SMILES
OC(/C=C\C(O)=O)=O.ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2.OC(/C=C\C(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [Content Brief]
[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ST-1006 Maleate Related Classifications
HY-120541A Related Classifications
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