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G140 

Cat. No.: HY-133916
Handling Instructions

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.

For research use only. We do not sell to patients.

G140 Chemical Structure

G140 Chemical Structure

CAS No. : 2369751-07-3

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Description

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

IC50 & Target

IC50: 14.0 nM (h-cGAS), 442 nM (m-cGAS)[1]

In Vitro

G140 (0.1-100 µM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC50s of 1.70 and 0.86 µM in human THP1 and primary macrophages, respectively[1].
G140 (0.1-100 µM; 24 h) inhibits cells viability with a LD50 of >100 µM in THP1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

379.24

Formula

C₁₇H₁₆Cl₂N₄O₂

CAS No.
SMILES

OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

G140G 140G-140OtherscyclicGMP-AMPsynthasecGASanti-inflammatoryInhibitorinhibitorinhibit

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