2369751-07-3
2369751-07-3
Chemical Structure
G140
- CAS No.: 2369751-07-3
- Formula:C17H16Cl2N4O2
- Molecular Weight:379.24
IUPAC Name: 1-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
InChIKey: NVPFAXHXXODQRO-UHFFFAOYSA-N
SMILES: OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O
Biological Activity: G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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G140 | 99.17% | G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-187079cGAS-IN-5-CH2-COOH -
Similarity Score 0.77
HY-147129cGAS-IN-9 -
Similarity Score 0.75
HY-128583G150 -
Similarity Score 0.70
HY-187080cGAS-IN-5-CH2-amido-C9-NH2 -
Similarity Score 0.56
HY-172208PROTAC cGAS degrader-1 -
Similarity Score 0.51
HY-162967MS8588 -
Similarity Score 0.51
HY-162966MS7829 -
Similarity Score 0.51
HY-164288TDI-6570 -
Similarity Score 0.50
HY-170362cGAS-IN-4 -
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