2369751-07-3

G140 Chemical Structure
2369751-07-3

Chemical Structure

G140

  • CAS No.: 2369751-07-3
  • Formula:C17H16Cl2N4O2
  • Molecular Weight:379.24

IUPAC Name: 1-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one

InChIKey: NVPFAXHXXODQRO-UHFFFAOYSA-N

SMILES: OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O

Biological Activity: G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

Cat. No. Product Name Purity Description Pricing
HY-133916 		G140 99.17% G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.
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