1. GPCR/G Protein
  2. Guanylate Cyclase
  3. Plecanatide

Plecanatide 

Cat. No.: HY-108741 Purity: 98.90%
Handling Instructions

Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.

For research use only. We do not sell to patients.

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Plecanatide Chemical Structure

Plecanatide Chemical Structure

CAS No. : 467426-54-6

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5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 470 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis[1][2][3].

IC50 & Target

EC50: 190 nM (guanylate cyclase-C)[1]

In Vitro

Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (2-4 month old) are induced colitis by TNBS[1]
Dosage: 0, 0.5 and 2.5 mg/kg
Administration: P.o. for 7 days
Result: Effectively reduced colitis severity scores as compared to vehicle treatment.
Clinical Trial
Molecular Weight

1681.89

Formula

C₆₅H₁₀₄N₁₈O₂₆S₄

CAS No.

467426-54-6

Sequence Shortening

NDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

PlecanatideGuanylate Cyclaseguanylatecyclase-CGC-Cchronicidiopathicconstipationanti-inflammatoryInhibitorinhibitorinhibit

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Plecanatide
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HY-108741
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