1. GPCR/G Protein
  2. Guanylate Cyclase

Plecanatide acetate 

Cat. No.: HY-108741A Purity: 99.26%
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Plecanatide acetate is a guanylate cyclase-C (GC-C) receptor agonist, with an EC50 of 190 nM in T84 cells. Plecanatide acetate shows anti-inflammatory activity in models of murine colitis.

For research use only. We do not sell to patients.

Plecanatide acetate Chemical Structure

Plecanatide acetate Chemical Structure

CAS No. : 1075732-84-1

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10 mM * 1 mL in DMSO USD 1629 In-stock
Estimated Time of Arrival: December 31
5 mg USD 490 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Description

Plecanatide acetate is a guanylate cyclase-C (GC-C) receptor agonist, with an EC50 of 190 nM in T84 cells. Plecanatide acetate shows anti-inflammatory activity in models of murine colitis[1].

IC50 & Target

EC50: 190 nM (guanylate cyclase-C receptor, T84 cells)[1]

In Vitro

Plecanatide acetate is a GC-C receptor agonist, binds and activates GC-C receptor, with an EC50 of 190 nM in T84 cells[1].

In Vivo

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice[1].

Animal Model: Female BALB/c mice (2-4 month old)[1]
Dosage: 0.5 and 2.5 mg/kg
Administration: P.O. for 7 days, with the first dose given the same day as TNBS
Result: Effectively reduced colitis severity scores in BALB/c mice.
Animal Model: BDF-1 mice (10-12 week old)[1]
Dosage: 0.005-5 mg/kg
Administration: P.O. once daily for 7 days
Result: Effective at 0.005 mg/kg as sulfasalazine (80 mg/kg) to ameliorate DSS induced colitis in BDF-1 mice, but had no incremental effect on the amelioration of colitis at higher doses than 0.005 mg/kg. Plecanatide at 0.05 mg/kg per day was as effective as 80 mg/kg per day of sulfasalazine.
Animal Model: TCRα-/- mice (sixteen week old)[1]
Dosage: 0.5 or 2.5 mg/kg
Administration: P.O. for 14 days
Result: Reduced colitis scores in TCRα-/- mice.
References
Molecular Weight

1741.94

Formula

C₆₇H₁₀₈N₁₈O₂₈S₄

CAS No.

1075732-84-1

SMILES

OC(C)=O.[NDECELCVNV ACTGCL]

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Plecanatide acetate
Cat. No.:
HY-108741A
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Plecanatide acetate

Cat. No.: HY-108741A