P2Y2R/GPR17 antagonist 1

Cat. No.: HY-146486 Pureza: 98.09%: Ficha de datos
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P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y₂R and GPR17 antagonist with IC₅₀ values of 3.17 µM and 1.67 µM against P2Y₂R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes.

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P2Y2R/GPR17 antagonist 1 Estructura química

No. CAS : 2395016-49-4

Tamaño	Stock	Cantidad

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas P2Y Receptor:

Ver todas las isoformas

P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

IC₅₀: 1.67 µM (GPR17), 3.17 µM (P2Y₂R)^[1]

Peso molecular

432.83

Fòrmula

C₁₉H₁₃ClN₂O₆S

No. CAS

2395016-49-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C=CC=C1)Cl)NC2=CC=C(C=C2)S(=O)(OC3=CC([N+]([O-])=O)=CC=C3)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (288.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3104 mL	11.5519 mL	23.1038 mL
5 mM	0.4621 mL	2.3104 mL	4.6208 mL
10 mM	0.2310 mL	1.1552 mL	2.3104 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.09%

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Ficha de datos (270 KB) SDS (252 KB)

COA (248 KB) HNMR (259 KB) LCMS (95 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3104 mL	11.5519 mL	23.1038 mL	57.7594 mL
	5 mM	0.4621 mL	2.3104 mL	4.6208 mL	11.5519 mL
	10 mM	0.2310 mL	1.1552 mL	2.3104 mL	5.7759 mL
	15 mM	0.1540 mL	0.7701 mL	1.5403 mL	3.8506 mL
	20 mM	0.1155 mL	0.5776 mL	1.1552 mL	2.8880 mL
	25 mM	0.0924 mL	0.4621 mL	0.9242 mL	2.3104 mL
	30 mM	0.0770 mL	0.3851 mL	0.7701 mL	1.9253 mL
	40 mM	0.0578 mL	0.2888 mL	0.5776 mL	1.4440 mL
	50 mM	0.0462 mL	0.2310 mL	0.4621 mL	1.1552 mL
	60 mM	0.0385 mL	0.1925 mL	0.3851 mL	0.9627 mL
	80 mM	0.0289 mL	0.1444 mL	0.2888 mL	0.7220 mL
	100 mM	0.0231 mL	0.1155 mL	0.2310 mL	0.5776 mL