1. GPCR/G Protein
  2. P2Y Receptor
  3. 2-Methylthio-AMP

2-Methylthio-AMP (Synonyms: 2-MeSAMP; 2-Methylthioadenosine 5′-monophosphate; 2-Methylthioadenosine 5′-phosphate)

Cat. No.: HY-125989
Handling Instructions

2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation.

For research use only. We do not sell to patients.

2-Methylthio-AMP Chemical Structure

2-Methylthio-AMP Chemical Structure

CAS No. : 22140-20-1

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2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3].

IC50 & Target


In Vitro

2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets[1].
2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


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