1. GPCR/G Protein
  2. P2Y Receptor
  3. 2-Methylthio-AMP diTEA

2-Methylthio-AMP diTEA (Synonyms: 2-MeSAMP diTEA; 2-Methylthioadenosine 5′-monophosphate diTEA; 2-Methylthioadenosine 5′-phosphate diTEA)

Cat. No.: HY-125989B
Handling Instructions

2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation.

For research use only. We do not sell to patients.

2-Methylthio-AMP diTEA Chemical Structure

2-Methylthio-AMP diTEA Chemical Structure

CAS No. : 1227193-98-7

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Description

2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].

IC50 & Target

P2Y12[1]

In Vitro

2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets[1].
2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

595.69

Formula

C₂₃H₄₆N₇O₇PS

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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2-Methylthio-AMP diTEA
Cat. No.:
HY-125989B
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