1227193-98-7
Chemical Structure
2-Methylthio-AMP diTEA
Synonym(s): 2-MeSAMP diTEA; 2-Methylthioadenosine 5′-monophosphate diTEA; 2-Methylthioadenosine 5′-phosphate diTEA
- CAS No.: 1227193-98-7
- Formula:C23H46N7O7PS
- Molecular Weight:595.69
IUPAC Name: triethylamine hemi(((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate)
InChIKey: KILPFOKXXXUFNN-IDIVVRGQSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C3=NC(SC)=NC(N)=C3N=C2)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Biological Activity: 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
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2-Methylthio-AMP diTEA | 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation. | |||||||||||||||||||||
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- [1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [Content Brief]
- [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [Content Brief]
- [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22. [Content Brief]
Keywords
