1. GPCR/G Protein
  2. P2Y Receptor
  3. MRS2500 tetraammonium

MRS2500 tetraammonium 

Cat. No.: HY-108658
Handling Instructions

MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Antithrombotic activity.

For research use only. We do not sell to patients.

MRS2500 tetraammonium Chemical Structure

MRS2500 tetraammonium Chemical Structure

CAS No. : 630103-23-0

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Description

MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Antithrombotic activity[1][2][3].

In Vitro

MRS2500 tetraammonium inhibits platelet aggregation to 10 μM ADP with an IC50 of 0.95 nM in human washed platelets. MRS2500 tetraammonium inhibits platelet aggregation to 10μM ADP with an IC50 of 0.49 μM in human PRP[4].

In Vivo

MRS2500 (2 mg/kg; i.v.) decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor[3].
MRS2500 exhibited strong antithrombotic efficacy in the prevention of arterial thrombosis in the monkey ECAT model[4]..

Animal Model: 20-25 g WT Male mice (acute vascular occlusion model)[3]
Dosage: 2 mg/kg
Administration: Intravenous
Result: Reduced platelet consumption.
Molecular Weight

629.28

Formula

C₁₃H₃₀IN₉O₈P₂

CAS No.

630103-23-0

SMILES

O=P(O[[email protected]@H]1[[email protected]]2(COP(O[NH4])(O[NH4])=O)C[[email protected]]2([H])[[email protected]@H](N3C=NC4=C(NC)N=C(I)N=C34)C1)(O[NH4])O[NH4]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MRS2500 tetraammoniumP2Y ReceptorADPplateletaggregationacutesystemicthromboembolismarterialthrombosisInhibitorinhibitorinhibit

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MRS2500 tetraammonium
Cat. No.:
HY-108658
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