MRS2500 tetraammonium

Name: MRS2500 tetraammonium
Brand: MedChemExpress
SKU: HY-108658
Rating: 4.5 (1 reviews)

Cat. No.: HY-108658 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (K_i=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Antithrombotic activity.

For research use only. We do not sell to patients.

MRS2500 tetraammonium Chemical Structure

CAS No. : 630103-23-0

Size	Price	Stock	Quantity
1 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
2 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2850	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

MRS2500 tetraammonium inhibits platelet aggregation to 10 μM ADP with an IC₅₀ of 0.95 nM in human washed platelets. MRS2500 tetraammonium inhibits platelet aggregation to 10μM ADP with an IC₅₀ of 0.49 μM in human PRP^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MRS2500 (2 mg/kg; i.v.) decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor^[3].
MRS2500 exhibited strong antithrombotic efficacy in the prevention of arterial thrombosis in the monkey ECAT model^[4]..

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-25 g WT Male mice (acute vascular occlusion model)^[3]
Dosage:	2 mg/kg
Administration:	Intravenous
Result:	Reduced platelet consumption.

Molecular Weight

629.28

Formula

C₁₃H₃₀IN₉O₈P₂

CAS No.

630103-23-0

Appearance

Solid

Color

White to off-white

SMILES

O=P(O[C@@H]1[C@]2(COP(O[NH4])(O[NH4])=O)C[C@]2([H])[C@@H](N3C=NC4=C(NC)N=C(I)N=C34)C1)(O[NH4])O[NH4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (79.46 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5891 mL	7.9456 mL	15.8912 mL
5 mM	0.3178 mL	1.5891 mL	3.1782 mL
10 mM	0.1589 mL	0.7946 mL	1.5891 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (281 KB) SDS (251 KB)

COA (260 KB) HNMR (447 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Cattaneo M, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004;68(10):1995-2002. [Content Brief]

[2]. Wong PC, et al. The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. J Thromb Thrombolysis. 2016;41(3):514-521. [Content Brief]

[3]. Hechler B, et al. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther. 2006;316(2):556 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5891 mL	7.9456 mL	15.8912 mL	39.7279 mL
	5 mM	0.3178 mL	1.5891 mL	3.1782 mL	7.9456 mL
	10 mM	0.1589 mL	0.7946 mL	1.5891 mL	3.9728 mL
	15 mM	0.1059 mL	0.5297 mL	1.0594 mL	2.6485 mL
	20 mM	0.0795 mL	0.3973 mL	0.7946 mL	1.9864 mL
	25 mM	0.0636 mL	0.3178 mL	0.6356 mL	1.5891 mL
	30 mM	0.0530 mL	0.2649 mL	0.5297 mL	1.3243 mL
	40 mM	0.0397 mL	0.1986 mL	0.3973 mL	0.9932 mL
	50 mM	0.0318 mL	0.1589 mL	0.3178 mL	0.7946 mL
	60 mM	0.0265 mL	0.1324 mL	0.2649 mL	0.6621 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.