Clopidogrel
Based on 31 publication(s) in Google Scholar
Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
For research use only. We do not sell to patients.
- Purity: 98.43%
- CAS No.: 113665-84-2
- Formula: C16H16ClNO2S
- Molecular Weight:321.82
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications Citing Use of MedChemExpress (MCE) Clopidogrel
More- ACS Nano. 2023 Apr 11;17(7):6519-6533. [Abstract]
- Neuron. 2026 Apr 15;114(8):1419-1432.e7. [Abstract]
- Theranostics. 2023 Mar 27;13(6):2040-2056. [Abstract]
- J Adv Res. 2024 Jul 5:S2090-1232(24)00269-8. [Abstract]
- J Neuroinflammation. 2025 Dec 8. [Abstract]
- Int J Biol Sci. 2019 Jan 1;15(1):239-252. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- PLoS Biol. 2026 Feb 6;24(2):e3003642. [Abstract]
- Int J Mol Med. 2025 May;55(5):78. [Abstract]
- Biochem Pharmacol. 2025 Dec;242(Pt 3):117379. [Abstract]
- J Ethnopharmacol. 2024 Aug 22:118707. [Abstract]
- Foods. 2023 Feb 10;12(4):777. [Abstract]
- Drug Des Devel Ther. 2020 Dec 21:14:5599-5610. [Abstract]
- Int J Mol Sci. 2022 Aug 14;23(16):9118. [Abstract]
- Front Pharmacol. 2024 Oct 23:15:1496639. [Abstract]
- Front Pharmacol. 2022 Jan 10;12:792263. [Abstract]
- Front Pharmacol. 2021 Oct 8:12:734603. [Abstract]
- ACS Omega. 2020 Aug 4;5(32):19995-20003. [Abstract]
- J Food Biochem. 2020 Sep;44(9):e13352. [Abstract]
- iScience. 2024 Feb 5;27(3):109134. [Abstract]
- J Cell Physiol. 2026 Mar;241(3):e70160. [Abstract]
- Thromb Res. 2024 Jun:238:41-51. [Abstract]
- Thromb Res. 2023 Jul:227:17-24. [Abstract]
- J Appl Physiol (1985). 2021 Nov 1;131(5):1552-1564. [Abstract]
- Clin Chim Acta. 2025 Dec 31:120816. [Abstract]
- Thromb J. 2024 Jul 10;22(1):59. [Abstract]
- Open Chem. 2020 Jun.
- Am J Transl Res. 2020 May 15;12(5):1741-1753. [Abstract]
- J Pharm Health Care Sci. 2021 May 4;7(1):18. [Abstract]
- University of Colorado Denver. 2024.
- Res Sq. 2023 Nov 14:rs.3.rs-3474507. [Abstract]
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Cell Imaging/Staining
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WB
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Histological Imaging/Staining
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RT-PCR
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WB
All P2Y Receptor Isoforms
More
Biological Activity
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P2Y12 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | ED50 |
4.13 mg/kg
Compound: Clopidogrel
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Anti-platelet activity against ADP-induced platelet aggregation in rat assessed as inhibition of platelet aggregation
Anti-platelet activity against ADP-induced platelet aggregation in rat assessed as inhibition of platelet aggregation
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[PMID: 36058469] |
| Platelet | IC50 |
7.6 μM
Compound: Clopidogrel
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Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
|
10.1039/C4MD00022F |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 113665-84-2
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Appearance Oil
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Molecular Weight 321.82
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Formula C16H16ClNO2S
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Color Colorless to light yellow
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SMILES
ClC1=C(C=CC=C1)[C@H](N2CCC3=C(C2)C=CS3)C(OC)=O
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Synonyms
Clopidogrelum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (31)
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Journal Impact Factor
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Most Recent
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ACS Nano
Cryo-Shocked Platelet Coupled with ROS-Responsive Nanomedicine for Targeted Treatment of Thromboembolic Disease. [Abstract]2023 Apr 11;17(7):6519-6533. PMID: 36971410 -
Neuron
More than microglial depletion: PLX5622 activates the hepatic constitutive androstane receptor to alter anesthesia and addiction. [Abstract]2026 Apr 15;114(8):1419-1432.e7. PMID: 41734759 -
Theranostics
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages. [Abstract]2023 Mar 27;13(6):2040-2056. PMID: 37064877 -
J Adv Res
2024 Jul 5:S2090-1232(24)00269-8. PMID: 38972542 -
J Neuroinflammation
Hyperglycemia impairs microglia responding to retinal vasculopathy via enhanced norepinephrine-ADRB2 signaling. [Abstract]2025 Dec 8. PMID: 41361454
Clopidogrel purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Dec 8. [Abstract]
In vehicle-treated retinas, microglial processes rapidly converged toward the injury site within 30 min. This response was markedly suppressed by Clopidogrel (10 mg/kg, i.p.) treatment.
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Int J Biol Sci
Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis. [Abstract]2019 Jan 1;15(1):239-252. PMID: 30662363
Clopidogrel purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252. [Abstract]
Representative images of kidney tissue H&E (upper panel) and Sirius red staining (lower panel) of control (Ctl) and diabetic mice (DM) with or without Clopidogrel (20 mg/kg, p.o.) treatment (Ctl + Clo & DM + Clo).
Clopidogrel purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252. [Abstract]
RT-PCR analysis of the T1D kidney tissue showed significantly elevated mRNA levels of ECM molecules, such as FN and collagen I, which were reduced by the Clopidogrel (20 mg/kg, p.o.) treatment.
Clopidogrel purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252. [Abstract]
Western blot analysis confirmed that the T1D-induced increase in the FN expression at six months was decreased by the Clopidogrel (20 mg/kg, p.o.) treatment.
Clopidogrel purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2019 Jan 1;15(1):239-252. [Abstract]
The Clopidogrel (20 mg/kg, p.o.) treatment did not affect the body weight, however, it significantly decreased the blood glucose.
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
PLoS Biol
Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling. [Abstract]2026 Feb 6;24(2):e3003642. PMID: 41650189 -
Int J Mol Med
Platelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling. [Abstract]2025 May;55(5):78. PMID: 40084691 -
Biochem Pharmacol
2025 Dec;242(Pt 3):117379. PMID: 41046073 -
J Ethnopharmacol
Mailuoning oral liquid ameliorates vasculitis in thromboangiitis obliterans rats via inactivating cGAS-STING-IRF3 and TLR4-MAPKs/NF-κB signaling pathways. [Abstract]2024 Aug 22:118707. PMID: 39181282 -
Foods
Structural Insights on Hyp-Gly-Containing Peptides as Antiplatelet Compounds through Topomer CoMFA and CoMSIA Analysis. [Abstract]2023 Feb 10;12(4):777. PMID: 36832851 -
Drug Des Devel Ther
Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157. [Abstract]2020 Dec 21:14:5599-5610. PMID: 33376304 -
Int J Mol Sci
Rescue of Mitochondrial SIRT3 Ameliorates Ischemia-like Injury in Human Endothelial Cells. [Abstract]2022 Aug 14;23(16):9118. PMID: 36012382 -
Front Pharmacol
Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond. [Abstract]2024 Oct 23:15:1496639. PMID: 39508046 -
Front Pharmacol
Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic-Reperfusion Injury in Rats. [Abstract]2022 Jan 10;12:792263. PMID: 35082674 -
Front Pharmacol
Berberine and Its Main Metabolite Berberrubine Inhibit Platelet Activation Through Suppressing the Class I PI3Kβ/Rasa3/Rap1 Pathway. [Abstract]2021 Oct 8:12:734603. PMID: 34690771 -
ACS Omega
Purification and Characterization of Novel Collagen Peptides against Platelet Aggregation and Thrombosis from Salmo salar. [Abstract]2020 Aug 4;5(32):19995-20003. PMID: 32832753 -
J Food Biochem
A novel di-peptide Met-Glu from collagen hydrolysates inhibits platelet aggregation and thrombus formation via regulation of Gq-mediated signaling. [Abstract]2020 Sep;44(9):e13352. PMID: 32662128 -
iScience
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice. [Abstract]2024 Feb 5;27(3):109134. PMID: 38375215 -
J Cell Physiol
Distinct Thromboxane A₂-Dependent Pathways Regulate Arachidonic Acid-Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition. [Abstract]2026 Mar;241(3):e70160. PMID: 41800570 -
Thromb Res
2024 Jun:238:41-51. PMID: 38669962 -
Thromb Res
OKL-1111, A modified cyclodextrin as a potential universal reversal agent for anticoagulants. [Abstract]2023 Jul:227:17-24. PMID: 37207560 -
J Appl Physiol (1985)
Intravital assessment of precapillary pulmonary arterioles of type 1 diabetic mice shows oxidative damage and increased tone in response to NOS inhibition. [Abstract]2021 Nov 1;131(5):1552-1564. PMID: 34590907 -
Clin Chim Acta
Simultaneous quantification of acetylsalicylic acid, clopidogrel, ticagrelor and their major metabolites in human plasma by liquid chromatography-tandem mass spectrometry. [Abstract]2025 Dec 31:120816. PMID: 41482259 -
Thromb J
Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy. [Abstract]2024 Jul 10;22(1):59. PMID: 38987792 -
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Am J Transl Res
Role of MKP-5-p38/MAPK pathway in Clopidogrel-induced gastric mucosal epithelial cells apoptosis and tight junction dysfunction. [Abstract]2020 May 15;12(5):1741-1753. PMID: 32509173
Clopidogrel purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2020 May 15;12(5):1741-1753. [Abstract]
Expression of MKP-5 and phosphorylated p38/MAPK in Clopidogrel-treated gastric mucosal tissues and cells. Western blot analysis show MKP-5 is decreased and negatively correlated of Clopidogrel.
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J Pharm Health Care Sci
Mixture of clopidogrel bisulfate and magnesium oxide tablets reduces clopidogrel dose administered through a feeding tube. [Abstract]2021 May 4;7(1):18. PMID: 33941283 -
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Res Sq
Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs. [Abstract]2023 Nov 14:rs.3.rs-3474507. PMID: 38014223
Solvent & Solubility
DMSO : 50 mg/mL (155.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
Mice[1]
13-week-old C57BL/6J male mice are used throughout the study. After 1 week of acclimation, 15 mice are injected I.P. with streptozotocin (STZ) at a dosage of 55 mg/kg body weight daily for five consecutive days. Additional 15 mice as controls (Ctrl) are injected with a vehicle solution (0.1 mol/L citrate acid buffer, pH 4.3-4.5). Seven days after the last STZ administration, hyperglycemic mice (3-hour fasting blood glucose ≥250 mg/dL) are considered T1D (DM). This time point is defined as a baseline. Three months after diabetes induction, five diabetic and five control mice are sacrificed and blood and kidneys harvested. The remaining animals are divided in four groups: Normal control with vehicle (Ctrl), Normal control with Clopidogrel (Ctrl+ Clo), T1D (DM) with vehicle, and DM with Clopidogrel treatment (DM+Clo) and are treated with 20 mg/kg b.w./day Clopidogrel or with vehicle administered in their drinking water for three additional months. At the end of experiment, mice are intraperitoneally anesthetized with Avertin (tribromoethanol, 350 mg/kg) and sacrificed to collect blood and kidneys for mRNA, protein, and histological analyses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1073 mL | 15.5366 mL | 31.0733 mL | 77.6832 mL |
| 5 mM | 0.6215 mL | 3.1073 mL | 6.2147 mL | 15.5366 mL | |
| 10 mM | 0.3107 mL | 1.5537 mL | 3.1073 mL | 7.7683 mL | |
| 15 mM | 0.2072 mL | 1.0358 mL | 2.0716 mL | 5.1789 mL | |
| 20 mM | 0.1554 mL | 0.7768 mL | 1.5537 mL | 3.8842 mL | |
| 25 mM | 0.1243 mL | 0.6215 mL | 1.2429 mL | 3.1073 mL | |
| 30 mM | 0.1036 mL | 0.5179 mL | 1.0358 mL | 2.5894 mL | |
| 40 mM | 0.0777 mL | 0.3884 mL | 0.7768 mL | 1.9421 mL | |
| 50 mM | 0.0621 mL | 0.3107 mL | 0.6215 mL | 1.5537 mL | |
| 60 mM | 0.0518 mL | 0.2589 mL | 0.5179 mL | 1.2947 mL | |
| 80 mM | 0.0388 mL | 0.1942 mL | 0.3884 mL | 0.9710 mL | |
| 100 mM | 0.0311 mL | 0.1554 mL | 0.3107 mL | 0.7768 mL |