2. Metabolic Enzyme/Protease
    GPCR/G Protein
  3. Cytochrome P450
    P2Y Receptor
  4. Clopidogrel hydrogen sulfate

Clopidogrel hydrogen sulfate  (Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate)

Cat. No.: HY-17459 Purity: 99.75%
COA Handling Instructions

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.

For research use only. We do not sell to patients.

Clopidogrel hydrogen sulfate Chemical Structure

Clopidogrel hydrogen sulfate Chemical Structure

CAS No. : 120202-66-6

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10 mM * 1 mL in DMSO USD 73 In-stock
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Customer Review

Based on 15 publication(s) in Google Scholar

Other Forms of Clopidogrel hydrogen sulfate:

Top Publications Citing Use of Products

    Clopidogrel hydrogen sulfate purchased from MCE. Usage Cited in: Am J Transl Res. 2020 May 15;12(5):1741-1753.  [Abstract]

    Expression of MKP-5 and phosphorylated p38/MAPK in Clopidogrel-treated gastric mucosal tissues and cells. Western blot analysis show MKP-5 is decreased and negatively correlated of Clopidogrel.

    View All Cytochrome P450 Isoform Specific Products:

    View All Isoforms
    CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 CYP19 CYP26 CYP51

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    • Customer Review

    Description

    Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].

    IC50 & Target[1]

    CYP2B6

    18.2 nM (IC50)

    P2Y12 Receptor

     

    CYP2C19

    524 nM (IC50)

    In Vitro

    Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis[3].
    Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[3]

    Cell Line: GES-1 cells
    Concentration: 1.5 mM
    Incubation Time: 12 and 24 hours
    Result: The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.
    The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.

    Apoptosis Analysis[3]

    Cell Line: Gastric epithelial cell (GES-1) cells
    Concentration: 1.5 mM
    Incubation Time: 24 hours
    Result: Induced apoptosis of gastric epithelial cells．
    In Vivo

    Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age[4]
    Dosage: 5 mg/kg
    Administration: Gavage treatment
    Result: Clopidogrel significantly inhibited thrombus formation compared with vehicle.
    When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone.
    In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
    Clinical Trial
    Molecular Weight

    419.90

    Appearance

    Solid

    Formula

    C16H18ClNO6S2
    CAS No.
    SMILES

    ClC1=C([[email protected]@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46.7 mg/mL (111.22 mM)

    H2O : 16.67 mg/mL (39.70 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3815 mL 11.9076 mL 23.8152 mL
    5 mM 0.4763 mL 2.3815 mL 4.7630 mL
    10 mM 0.2382 mL 1.1908 mL 2.3815 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (119.08 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.75%

    COA (257 KB) LCMS (268 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Clopidogrel hydrogen120202-66-6(S)-(+)-Clopidogrel bisulfate(S)-(+)-Clopidogrel hydrogenCytochrome P450P2Y ReceptorCYPsAntiplateletbloodclotCYP2B6CYP2C19antithromboticplateletaggregationInhibitorinhibitorinhibit

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    Cat. No.:
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