1. GPCR/G Protein
  2. P2Y Receptor
  3. YM-254890

YM-254890 

Cat. No.: HY-111557 Purity: ≥99.0%
COA Handling Instructions

YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM.

For research use only. We do not sell to patients.

YM-254890 Chemical Structure

YM-254890 Chemical Structure

CAS No. : 568580-02-9

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1 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE YM-254890

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Description

YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM[1][2].

IC50 & Target

Gαq/11 protein[1][2]

In Vitro

YM-254890 inhibits platelet aggregation induced by ADP (2, 5 and 20 μM) in human platelet-rich plasma with IC50 values of 0.37, 0.39 and 0.51 μM. ADP mediates platelet aggregation via two G protein-coupled receptors, P2Y1 and P2Y12. The effect of YM-254890 on the P2Y1 and P2Y12 signal transduction pathways using C6-15 cells stably expressing the human P2Y1 or P2Y12 receptors is examined. Stimulation of P2Y1-C6-15 cells by 2MeSADP leads to increases in intracellular calcium mobilization. In this assay, YM-254890 inhibits the increase in [Ca2+]i with an IC50 value of 0.031 μM. In contrast, 2MeSADP-induced inhibition of forskolin-stimulated adenylyl cyclase activity in P2Y12-C6-15 cells is unaffected by YM-254890 at 40 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

960.08

Formula

C46H69N7O15

CAS No.
SMILES

CN([[email protected]@H](C)C(N[[email protected]@H]([[email protected]](OC([[email protected]@H](NC(C)=O)[[email protected]@H](C(C)C)O)=O)C(C)C)C(N(C)[[email protected]@H]([[email protected]](OC)C)C(O[[email protected]@H]1C)=O)=O)=O)C([[email protected]](C)NC(C(N(C([[email protected]@H](CC2=CC=CC=C2)OC([[email protected]]1NC(C)=O)=O)=O)C)=C)=O)=O

Structure Classification
Source

the culture broth of Chromobacterium sp

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
YM-254890
Cat. No.:
HY-111557
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