568580-02-9
Chemical Structure
YM-254890
- CAS No.: 568580-02-9
- Formula:C46H69N7O15
- Molecular Weight:960.08
IUPAC Name: (R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
InChIKey: QVYLWCAYZGFGNF-WBWCVGBTSA-N
SMILES: CN([C@@H](C)C(N[C@@H]([C@H](OC([C@@H](NC(C)=O)[C@@H](C(C)C)O)=O)C(C)C)C(N(C)[C@@H]([C@H](OC)C)C(O[C@@H]1C)=O)=O)=O)C([C@H](C)NC(C(N(C([C@@H](CC2=CC=CC=C2)OC([C@H]1NC(C)=O)=O)=O)C)=C)=O)=O
Biological Activity: YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YM-254890 | 99.18% | YM-254890 is a selective Gαq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway, with an IC50 value below 0.6 μM. | ||||||||||||||||||||
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- [1]. Taniguchi M, et al. YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666. J Antibiot (Tokyo). 2003 Apr;56(4):358-63. [Content Brief]
- [2]. Zhang H, et al. Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem. 2018 Aug 5;156:847-860. [Content Brief]
Keywords
