2. Others Anti-infection GPCR/G Protein Metabolic Enzyme/Protease
  3. Drug Derivative Bacterial P2Y Receptor Endogenous Metabolite
  4. YM-254891

YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation.

For research use only. We do not sell to patients.

YM-254891

YM-254891 Chemical Structure

CAS No. : 726188-99-4

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YM-254891 Related Antibodies

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Description

YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation[1].

IC50 & Target[1]

Microbial Metabolite

 

In Vitro

YM-254891 inhibits 2MeSADP-induced Ca2+ influx in P2Y1-C6-15 cells with an IC50 of 0.23 μM[1].
YM-254891 inhibits ADP-induced platelet aggregation in platelet-rich plasma with an IC50 of 0.27 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YM-254891 Related Antibodies
Molecular Weight

974.10

Formula

C47H71N7O15
CAS No.
SMILES

CCC(N[C@@H]([C@H](O)C(C)C)C(O[C@@H]([C@@]1([H])C(N([C@@](C(O[C@@H]([C@@H](C(O[C@@H](C(N(C(C(N[C@H](C(N([C@H](C(N1)=O)C)C)=O)C)=O)=C)C)=O)CC2=CC=CC=C2)=O)NC(C)=O)C)=O)([H])[C@@H](C)OC)C)=O)C(C)C)=O)=O
Structure Classification
Initial Source

Chromobacterium sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YM-254891 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-254891726188-99-4YM254891YM 254891Drug DerivativeBacterialP2Y ReceptorEndogenous MetaboliteDrug derivativeADPGαq/11Ca2? influxP2Y?-C?-15 cellshuman platelet-rich plasma2MeSADPGαq/11 proteinplatelet aggregationthromboembolic diseasesInhibitorinhibitorinhibit

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