2. Apoptosis Stem Cell/Wnt MAPK/ERK Pathway
  3. Apoptosis ERK
  4. FR900359

FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin (HY-W250978A)-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research.

For research use only. We do not sell to patients.

CAS No. : 107530-18-7

Size Price Stock Quantity
250 μg In-stock
500 μg In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

FR900359 Related Antibodies

Top Publications Citing Use of Products

    FR900359 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2026 Feb 9.  [Abstract]

    Western blot of phospho-ERK in GqC-PSCs treated with the α1-agonist PE or 1 µM of DCZ in the presence or absence of the selective Gαq inhibitor FR900359 (1 μM).

    FR900359 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2026 Feb 9.  [Abstract]

    FR900359 (1 μM) led to a complete abrogation of the NE-induced [Ca2+]i signal, confirming that this calcium response is Gαq-dependent.

    FR900359 purchased from MedChemExpress. Usage Cited in: Neuron. 2025 Nov 26:S0896-6273(25)00842-6.  [Abstract]

    WT mice were injected with AAV2/9-E-SARE-ERT2-CreERT2-PEST and AAV2/9-CAG-FLEX-H3R-EGFP in the PVT. PVTHFD neurons were labeled with tamoxifen injection-paired HFD supply and EGFP-positive neurons were patched during electrophysiological assays. Representative firing curves of PVTHFD neurons after 100-pA depolarizing current injection (left), and the firing frequency with 0–100-pA depolarizing current injection (right) before and at 20 min FR900359 (10 μM, n = 10 cells) perfusion. The phosphorylation levels of the downstream proteins were determined by western blotting and shown in the lower right corner.

    FR900359 purchased from MedChemExpress. Usage Cited in: Neuron. 2025 Nov 26:S0896-6273(25)00842-6.  [Abstract]

    HDC-CreERT2 mice were injected with AAV2/9-CAG-FLEX-mCherry (AAV-FLEX-mCherry) or AAV2/9-CAG-FLEX-oChIEF-mCherry (AAV-FLEX-oChIEFmCherry) in the TMN. An optical fiber and a cannula were implanted in the PVT. Mice were exposed to blue (λ = 473 nm) or yellow (λ = 598 nm) light as indicated. Mice underwent HFD normal feeding test. Rhosin (10 μM), FR900359 (10 μM), or Barbadin (30 μM) diluted in saline was injected via the cannula before the test. n = 6 male mice in oChIEF + yellow light + saline group; 5 male mice in mCherry + blue light + saline group; 9 male mice in oChIEF + blue light+ saline group; 8 male mice in oChIEF + blue light + Rhosin group; 7 male mice in oChIEF + blue light + FR900359 group; 6 male mice in oChIEF + blue light + Barbadin group. blue light + FR900359 (1 μM).

    View All ERK Isoform Specific Products:

    View All Isoforms
    ERK ERK1 ERK2 ERK5 ERK8

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin (HY-W250978A)-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research[1][2][3][4].

    In Vitro

    FR900359 (1.0 μM, 1 hours) inhibits Gαq, Gα11 and Gα /14, but not Gα16 or any other mammalian Gα isoform in HEK293 cells[1].
    FR900359 (0-10 μM, 24 hours) effectively reduces growth of B16 cells and suppressed cell proliferation and inhibits migration in a concentration-dependent manner[1].
    FR900359 (10 nM, 72 hours) induces G1 cell cycle arrest in melanoma cells with Gq tone and forces melanoma cells (B16 cells) into differentiation [1].
    FR900359 (1.0 μM, 5 min) interdicts the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) that be largely Gq-mediated28[1].
    FR900359 (1 μM, 24 hours) significantly induces more 92.1 cells undergoing apoptosis compared to untreated [3].
    FR900359 (30 nM, 60 min) induces dose-dependent relaxation of murine, porcine, and human airways ex vivo[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    FR900359 Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: B16 cells
    Concentration: 0-10 μM
    Incubation Time: 24 hours
    Result: Effectively reduced growth of B16 cells in a concentration-dependent manner and suppressed cell proliferation and migration.

    Cell Differentiation Assay[1]

    Cell Line: B16 cells
    Concentration: 10 nM
    Incubation Time: 72 hours
    Result: Induced G1 cell cycle arrest in melanoma cells with Gq tone.
    Treated cells appeared flattened, rather dark, and packed with melanin vesicles, attributes consistent with the adoption of a more differentiated state.
    Made melanocyte differentiation marker gp100 was upregulated considerably on FR treatment.

    Western Blot Analysis[1]

    Cell Line: HEK293 cells
    Concentration: 1.0 μM
    Incubation Time: 5 min
    Result: FR interdicts Gq-dependent ERK1/2 activation

    Apoptosis Analysis[3]

    Cell Line: 92.1 cells
    Concentration: 1.0 μM
    Incubation Time: 24 hours
    Result: Significantly induced more 92.1 cells undergoing apoptosis compared to untreated cells
    In Vivo

    FR900359 (0.2 or 1 mg/ml, 12 μL per mouse, i.v.) strongly reduces vascular tone in mouse tail artery[1].
    FR900359 (0.1 mg/ml, 2.5 mg/mouse, intratracheally) abolishes airway hyperreactivity after Ovalbumin (HY-W250978)-induced sensitization in mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Isometric force measurements in mouse tail artery [1]
    Dosage: 1.0 μM
    Administration: Washed
    Result: Strongly reduced vascular tone
    Animal Model: Ovalbumins–induced sensitization model of asthma. [4]
    Dosage: 0.1 mg/ml, 2.5 mg per mouse
    Administration: Intratracheally
    Result: Abolished airway hyperreactivity after ovalbumin-induced sensitization in mice
    Molecular Weight

    1002.16

    Formula

    C49H75N7O15
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to brown

    SMILES

    CC(C)[C@@H](O)[C@H](NC(CC)=O)C(O[C@@H]([C@H](NC([C@H](C)N(C)C([C@H](C)NC(C(N(C)C([C@@H](CC1=CC=CC=C1)O2)=O)=C)=O)=O)=O)C(N(C)[C@@H]([C@H](OC)C)C(O[C@H](C(C)C)[C@H](NC(C)=O)C2=O)=O)=O)C(C)C)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation

    Purity: 99.90%

    SDS (394 KB)

    COA (262 KB)

    Handling Instructions (2659 KB)
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    FR900359 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    FR900359107530-18-7FR 900359FR-900359ApoptosisERKExtracellular signal regulated kinasesB16，92.1 cellsmelanomaasthmablood pressureInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    FR900359
    Cat. No.:
    HY-117037
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB) Italian - IT (394 KB) Korean - KR (394 KB) Portuguese - PT (394 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.