2. Natural Products
  3. Disease Research Fields Plants Phenylpropanoids Phenols
  4. Rutaceae Inflammation/Immunology Lignans Monophenols
  5. Zanthoxylum chalybeum Engl.
  6. Ailanthoidol

Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion.

For research use only. We do not sell to patients.

Ailanthoidol Chemical Structure

Ailanthoidol Chemical Structure

CAS No. : 156398-61-7

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Ailanthoidol Related Antibodies

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Description

Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion[1][2].

In Vitro

Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages[1].
Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells[1].
Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6[1].
Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ailanthoidol Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0 μM, 1.25 μM, 2.5 μM,5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Inhibited LPS-induced NO and PGE2 secretion in a dose-dependent manner.
In Vivo

Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male BALB/c mice[1]
Dosage: 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days
Result: Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group.
Molecular Weight

326.34

Formula

C19H18O5
CAS No.
SMILES

OC1=CC=C(C2=CC3=CC(/C=C/CO)=CC(OC)=C3O2)C=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ailanthoidol156398-61-7Othersanti-inflammatoryantitumorchemopreventiveInhibitorinhibitorinhibit

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