Ailanthoidol
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion.
For research use only. We do not sell to patients.
- CAS No.: 156398-61-7
- Formula: C19H18O5
- Molecular Weight:326.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages[1].
Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells[1].
Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6[1].
Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:0 μM, 1.25 μM, 2.5 μM,5 μM, 10 μM, 20 μM
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Incubation Time:24 hours
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Result:Inhibited LPS-induced NO and PGE2 secretion in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old male BALB/c mice[1]
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Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days
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Result:Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group.
Chemical Information
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CAS No. 156398-61-7
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Molecular Weight 326.34
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Formula C19H18O5
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SMILES
OC1=CC=C(C2=CC3=CC(/C=C/CO)=CC(OC)=C3O2)C=C1OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jin-Kyung Kim, et al. Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Cell Biochem. 2011 Dec;112(12):3816-23. [Content Brief]
[2]. Yean-Jang Lee, et al. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep. 2006 Oct;16(4):921-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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