1. Immunology/Inflammation
  2. COX
  3. Metamizole sodium hydrate

Metamizole sodium hydrate 

Cat. No.: HY-B1279 Purity: ≥98.0%
Handling Instructions

Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX)[1].

For research use only. We do not sell to patients.

Metamizole sodium hydrate Chemical Structure

Metamizole sodium hydrate Chemical Structure

CAS No. : 5907-38-0

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500 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Other Forms of Metamizole sodium hydrate:

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Description

Metamizole sodium hydrate is a potent analgesic drug that has been demonstrated to inhibit cyclooxygenase (COX)[1].

IC50 & Target

COX[1]

Clinical Trial
Molecular Weight

351.35

Formula

C₁₃H₁₈N₃NaO₅S

CAS No.
SMILES

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (284.62 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (284.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8462 mL 14.2308 mL 28.4616 mL
5 mM 0.5692 mL 2.8462 mL 5.6923 mL
10 mM 0.2846 mL 1.4231 mL 2.8462 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (284.62 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Metamizole sodiumCOXCyclooxygenaseInhibitorinhibitorinhibit

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Product Name:
Metamizole sodium hydrate
Cat. No.:
HY-B1279
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