Metamizole sodium 

Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is a cyclooxygenase-3 (COX-3) inhibitor^[1][2].

COX-3^[2]

Metamizole sodium inhibits COX-3 with an IC₅₀ value of 52 μM and COX-1 at a 6.6-fold higher concentration in insect cells^[2].
Metamizole (1-500 μM; 48 hours) significantly inhibits cell proliferation in pancreatic cancer cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metamizole sodium (500 mg/kg; i.p.; twice a day; for 7 days) diminishes the development of neuropathic pain symptoms in rats^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

333.34

C₁₃H₁₆N₃NaO₄S

68-89-3

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. A Jasiecka, et al. Pharmacological characteristics of metamizole. Pol J Vet Sci. 2014;17(1):207-14.  [Content Brief]

  [2]. N V Chandrasekharan, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21): 13926-13931.  [Content Brief]

  [3]. Manuela Malsy, et al. Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1. BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77.  [Content Brief]

  [4]. Renata Zajaczkowska, et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain. Pharmacol Rep. 2020 Oct;72(5):1310-1322.  [Content Brief]