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  3. Metamizole sodium

Metamizole sodium 

Cat. No.: HY-B1279A
Handling Instructions

Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is a cyclooxygenase-3 (COX-3) inhibitor.

For research use only. We do not sell to patients.

Metamizole sodium Chemical Structure

Metamizole sodium Chemical Structure

CAS No. : 68-89-3

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Description

Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is a cyclooxygenase-3 (COX-3) inhibitor[1][2].

IC50 & Target

COX-3[2]

In Vitro

Metamizole sodium inhibits COX-3 with an IC50 value of 52 μM and COX-1 at a 6.6-fold higher concentration in insect cells[2].
Metamizole (1-500 μM; 48 hours) significantly inhibits cell proliferation in pancreatic cancer cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Pancreatic cancer cell lines PaTu 8988t and Panc-1
Concentration: 1 μM, 10 μM, 100 μM, 250 μM, 500 μM
Incubation Time: 48 hours
Result: Significantly inhibited cell proliferation in the PaTu 8988t cell line; significantly inhibited cell proliferation in the pancreatic cancer cell line Panc-1 at 1-250 μM.
In Vivo

Metamizole sodium (500 mg/kg; i.p.; twice a day; for 7 days) diminishes the development of neuropathic pain symptoms in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (270-300 g), with peripheral neuropathic pain[4]
Dosage: 500 mg/kg
Administration: Intraperitoneal injection, twice a day, for 7 days
Result: Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.
Clinical Trial
Molecular Weight

333.34

Formula

C₁₃H₁₆N₃NaO₄S

CAS No.
SMILES

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MetamizoleCOXCyclooxygenaseanalgesicantipyreticantinociceptiveInhibitorinhibitorinhibit

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Metamizole sodium
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HY-B1279A
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