68-89-3
Chemical Structure
Metamizole sodium
Synonym(s): Dipyrone; Methamizole sodium
- CAS No.: 68-89-3
- Formula:C13H16N3NaO4S
- Molecular Weight:333.34
IUPAC Name: sodium ((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino)methanesulfonate
InChIKey: DJGAAPFSPWAYTJ-UHFFFAOYSA-M
SMILES: O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O
Biological Activity: Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Metamizole sodium | 98.0% | Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain. | ||||||||||||||||||||
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Metamizole-d3 sodium | Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor. | |||||||||||||||||||||
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References
- [1]. DPierre SC, et al. Inhibition of cyclooxygenases by dipyrone. Br J Pharmacol. 2007 Jun;151(4):494-503. [Content Brief]
- [2]. De Luna-Bertos E, et al. Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential. ScientificWorldJournal. 2013 Sep 19;2013:809891. [Content Brief]
- [3]. Malsy M, et al. Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1. BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77. [Content Brief]
- [4]. Zajaczkowska R, et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain. Pharmacol Rep. 2020 Oct;72(5):1310-1322. [Content Brief]
- [5]. Ince I, Aksoy M, et al. A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats. J Invest Surg. 2015 Jun;28(3):173-80. [Content Brief]
