1. Cell Cycle/DNA Damage
    NF-κB
    Membrane Transporter/Ion Channel
  2. PPAR
    NF-κB
    P-glycoprotein
  3. Convallatoxin

Convallatoxin 

Cat. No.: HY-N2453
Handling Instructions

Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.

For research use only. We do not sell to patients.

Convallatoxin Chemical Structure

Convallatoxin Chemical Structure

CAS No. : 508-75-8

Size Price Stock
5 mg USD 400 Ask For Quote & Lead Time
25 mg USD 950 Ask For Quote & Lead Time
50 mg USD 1650 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All PPAR Isoform Specific Products:

View All NF-κB Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3].

In Vitro

Convallatoxin induces HaCaT cell necroptosis[4].

In Vivo

Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4].

Molecular Weight

550.64

Formula

C₂₉H₄₂O₁₀

CAS No.

508-75-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ConvallatoxinPPARNF-κBP-glycoproteinPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243coliticinflammationsubstrateanti-inflammatoryanti-proliferativepsoriasisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Convallatoxin
Cat. No.:
HY-N2453
Quantity:
MCE Japan Authorized Agent: