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Punicalagin

17 Cited Publications
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Based on 17 publication(s) in Google Scholar

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.

For research use only. We do not sell to patients.

  • Purity: 99.89%
  • CAS No.: 65995-63-3
  • Formula: C48H28O30
  • Molecular Weight:1084.72
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Punicalagin Chemical Structure
    Punicalagin Chemical Structure
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
  • Experimental Validation Results for Punicalagin
CAS No.: 65995-63-3
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[email protected] [email protected]
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  • Punicalagin Chemical Structure
    Punicalagin Chemical Structure
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    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

    Customer Validation
     Body weight changes in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 Sep 3. [Abstract]

    Customer Validation
     T-705 and SAA significantly reduced viral copies in the liver in Female BALB/c mice aged 6–8 weeks after treatment with 20 mg/kg of Salvianolic acid A (SAA), Chebulinic Acid, Tannic acid, or Punicalagin via i.g. upon challenge once daily for 3 days. 300 mg/kg T-705 administered via i.g. was used as a positive control.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. The mRNA expression of the inflammatory factors Ccl6, Lgals3, C1qa, TYROBP, and CD74 in the brain tissues 48 h postoperatively, normalized to GAPDH for each sample. PUN can effectively reduce the inflammatory response in brain tissue after HIE, while the AKT signaling pathway inhibitor 3-MA reversed this therapeutic effect.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of HE staining in the cortex post-operatively.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative Western blot images and quantification of Bcl-2 and Bax expression three days post-operation in the cortex.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative TUNEL-stained (green) and DAPI-stained (blue) brain sections of the cortex three days post-operatively. Quantitative analysis of the percentage of TUNEL-positive cells in the cortex.

  • 1/16

    Punicalagin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Jan 1:136:156330. [Abstract]

    Customer Validation
     Punicalagin (PUN)-treated HIE group was administered various doses of PUN (10 and 20 mg/kg) 24 h before hypoxia by intraperitoneal (i.p.) injection at 24 h intervals in Sprague-Dawley (SD) rats. Representative images of immunohistochemical staining of p-AKT and immunofluorescence staining for p62 (red) and LC3 (green) in the cortex of each group at 72 h post-HI.

  • Punicalagin