65995-63-3
65995-63-3
Chemical Structure
Punicalagin
- CAS No.: 65995-63-3
- Formula:C48H28O30
- Molecular Weight:1084.72
IUPAC Name: 1,2,3,12,13,14-hexahydroxy-5,10-dioxo-8-(14,15,16,22,23,27,28,34,35,36,7-undecahydroxy-25,210,4,10-tetraoxo-25,210-dihydro-5,9-dioxa-2(1,6)-chromeno[5,4,3-cde]chromena-1,3(1,2)-dibenzenacyclodecaphane-6-yl)-5,7,8,10-tetrahydrodibenzo[f,h][1,4]dioxecine-7-carbaldehyde
InChIKey: ZJVUMAFASBFUBG-UYMKNUMKSA-N
SMILES: O=C(C1=C(C2=C(O)C(O)=C(O)C=C2C(O[C@@H]3[C@@H](CO4)OC(O)[C@H](OC5=O)[C@H]3OC(C6=CC(O)=C(O)C(O)=C6C7=C5C=C(O)C(O)=C7O)=O)=O)C(O)=C8O)OC(C(C1=C8O9)=C%10C9=O)=C(O)C(O)=C%10C%11=C(C4=O)C=C(O)C(O)=C%11O
Biological Activity: Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Punicalagin | 99.89% | Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19. | ||||||||||||||||||||
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Punicalagin (Standard) | 98.39% | Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19. | ||||||||||||||||||||
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Punicalin | 99.88% | Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity. | ||||||||||||||||||||
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Casuarinin | 99.19% | Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO-1, mFasL, sFasL and HSP-70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF-α-induced phosphorylation of MAPK and activation of NF-κB, downregulates the expression of iNOS, NF-κB, COX-2 and ICAM-1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase-3 and elevation of TNF-α, inhibits the growth of Candida albicans, and inhibits HSV-2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections. | ||||||||||||||||||||
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Colinin | Colinin is a globulin protein. Colinin can be isolated from flaxseed. | |||||||||||||||||||||
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Vescalagin | Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a Ki value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties. | |||||||||||||||||||||
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1,3-HHDP-4,6-HHDP-D-Glucopyranoside | 1,3-HHDP-4,6-HHDP-D-Glucopyranoside is a glucopyranoside derivative. | |||||||||||||||||||||
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Castalagin | Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections. | |||||||||||||||||||||
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Neochebulagic acid | 96.71% | Neochebulagic acid is isolated from Phyllanthus emblica L.. | ||||||||||||||||||||
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Casuarictin | 98.62% | Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research. | ||||||||||||||||||||
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Oenothein B | 96.38% | Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. | ||||||||||||||||||||
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Tellimagrandin II | 98.19% | Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Seeram NP, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagicacid and a total pomegranate tannin extract are enhanced in combination with otherpolyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7. [Content Brief]
- [2]. Lin CC, et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6. [Content Brief]
- [3]. Liu C, et al. Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Res. 2016 Oct;134:97-107. [Content Brief]
