65995-63-3
Chemical Structure
Punicalagin
- CAS No.: 65995-63-3
- Formula:C48H28O30
- Molecular Weight:1084.72
IUPAC Name: 1,2,3,12,13,14-hexahydroxy-5,10-dioxo-8-(14,15,16,22,23,27,28,34,35,36,7-undecahydroxy-25,210,4,10-tetraoxo-25,210-dihydro-5,9-dioxa-2(1,6)-chromeno[5,4,3-cde]chromena-1,3(1,2)-dibenzenacyclodecaphane-6-yl)-5,7,8,10-tetrahydrodibenzo[f,h][1,4]dioxecine-7-carbaldehyde
InChIKey: ZJVUMAFASBFUBG-UYMKNUMKSA-N
SMILES: O=C(C1=C(C2=C(O)C(O)=C(O)C=C2C(O[C@@H]3[C@@H](CO4)OC(O)[C@H](OC5=O)[C@H]3OC(C6=CC(O)=C(O)C(O)=C6C7=C5C=C(O)C(O)=C7O)=O)=O)C(O)=C8O)OC(C(C1=C8O9)=C%10C9=O)=C(O)C(O)=C%10C%11=C(C4=O)C=C(O)C(O)=C%11O
Biological Activity: Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3].
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Punicalagin | 99.89% | Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19. | ||||||||||||||||||||
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Punicalagin (Standard) | 98.39% | Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19. | ||||||||||||||||||||
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- [1]. Seeram NP, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagicacid and a total pomegranate tannin extract are enhanced in combination with otherpolyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7. [Content Brief]
- [2]. Lin CC, et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6. [Content Brief]
- [3]. Liu C, et al. Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Res. 2016 Oct;134:97-107. [Content Brief]
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