Tellimagrandin II
Based on 1 publication(s) in Google Scholar
Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 81571-72-4
- Formula: C41H30O26
- Molecular Weight:938.66
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tellimagrandin II
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
>10 μg/mL
Compound: 25
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Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
| HCT-8 | ED50 |
>10 μg/mL
Compound: 25
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Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
| KB | ED50 |
>10 μg/mL
Compound: 25
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Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
| TE-671 | ED50 |
>10 μg/mL
Compound: 25
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Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
Tellimagrandin II (40 µg/mL, 24 hours) disrupts the cell wall integrity of Staphylococcus aureus[2]. Tellimagrandin II (40 μg/mL, 5 hours) significantly inhibits mecA mRNA and PBP2a protein expression in Methicillin-Resistant Staphylococcus aureus[2]. Tellimagrandin II (50 μM, 6 hours) significantly inhibits LPS (HY-D1056)-induced NO production as well as NOS2 mRNA and protein expression in RAW264.7 cells[3]. Tellimagrandin II (25 or 50 μM, 12 hours) significantly inhibits LPS (HY-D1056)-induced COX-2 protein levels and PGE2 production in RAW264.7 cells[3]. Tellimagrandin II (12.5-50 μM, 10 minutes) shows significant AChE inhibitory activity, with the IC50 of 18.6 μM[4]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Methicillin-Resistant Staphylococcus aureus
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Concentration:40 μg/mL
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Incubation Time:5 h
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Result:Significantly reduced PBP2a protein levels.
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Cell Line:Methicillin-Resistant Staphylococcus aureus
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Concentration:40 μg/mL
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Incubation Time:5 h
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Result:Significantly reduced mecA mRNA expression.
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Cell Line:LPS (HY-D1056)-induced inflammation RAW264.7 cells (murine macrophages)
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Concentration:50 μM
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Incubation Time:6 h
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Result:Significantly reduced NOS2 gene expression levels induced by LPS (HY-D1056).
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Cell Line:LPS (HY-D1056)-induced inflammation RAW264.7 cells (murine macrophages)
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Concentration:25 和 50 μM
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Incubation Time:12 h
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Result:Significantly reduced LPS (HY-D1056)-induced COX-2 protein levels and PGE2 production.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine (HY-N0296)-induced amnesiac ICR mouse model[4]
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Dosage:100 and 200 mg/kg
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Administration:Oral gavage (p.o.), once daily for 10 days
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Result:Improved learning and memory functions in the passive avoidance and water maze tests.
Chemical Information
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CAS No. 81571-72-4
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Appearance Solid
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Molecular Weight 938.66
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Formula C41H30O26
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Color Light yellow to brown
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SMILES
O=C(OC[C@H]1O[C@@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[C@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H]1OC(C5=CC(O)=C(O)C(O)=C56)=O)C7=C6C(O)=C(O)C(O)=C7
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Synonyms
Eugeniin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Phytochemical profiling of Symplocos tanakana Nakai and S. sawafutagi Nagam. leaf and identification of their antioxidant and anti-diabetic potential. [Abstract]2023 Sep 5:233:115441. PMID: 37148699
Solvent & Solubility
DMSO : 100 mg/mL (106.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62(3):301-6. [Content Brief]
[2]. Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20(22):5790. [Content Brief]
[3]. Lin CY, et al. Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages. Life (Basel). 2021 Apr 30;11(5):411. [Content Brief]
[4]. Chen LG, et al. Hydrolysable Tannins Exhibit Acetylcholinesterase Inhibitory and Anti-Glycation Activities In Vitro and Learning and Memory Function Improvements in Scopolamine-Induced Amnesiac Mice. Biomedicines. 2021 Aug 23;9(8):1066. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0653 mL | 5.3267 mL | 10.6535 mL | 26.6337 mL |
| 5 mM | 0.2131 mL | 1.0653 mL | 2.1307 mL | 5.3267 mL | |
| 10 mM | 0.1065 mL | 0.5327 mL | 1.0653 mL | 2.6634 mL | |
| 15 mM | 0.0710 mL | 0.3551 mL | 0.7102 mL | 1.7756 mL | |
| 20 mM | 0.0533 mL | 0.2663 mL | 0.5327 mL | 1.3317 mL | |
| 25 mM | 0.0426 mL | 0.2131 mL | 0.4261 mL | 1.0653 mL | |
| 30 mM | 0.0355 mL | 0.1776 mL | 0.3551 mL | 0.8878 mL | |
| 40 mM | 0.0266 mL | 0.1332 mL | 0.2663 mL | 0.6658 mL | |
| 50 mM | 0.0213 mL | 0.1065 mL | 0.2131 mL | 0.5327 mL | |
| 60 mM | 0.0178 mL | 0.0888 mL | 0.1776 mL | 0.4439 mL | |
| 80 mM | 0.0133 mL | 0.0666 mL | 0.1332 mL | 0.3329 mL | |
| 100 mM | 0.0107 mL | 0.0533 mL | 0.1065 mL | 0.2663 mL |
Tellimagrandin II Related Classifications
HY-N9386 Related Classifications
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