1. Anti-infection
    Apoptosis
    Autophagy
  2. Fungal
    Ferroptosis
    Autophagy
  3. Ciclopirox

Ciclopirox (Synonyms: HOE296b)

Cat. No.: HY-B0450 Purity: 98.76%
Handling Instructions

Ciclopirox (Penlac) is a synthetic antifungal agent.

For research use only. We do not sell to patients.

Ciclopirox Chemical Structure

Ciclopirox Chemical Structure

CAS No. : 29342-05-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Ciclopirox (Penlac) is a synthetic antifungal agent. Target: Antifungal Ciclopirox is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. The mechanism of action of ciclopirox is poorly understood [1]. However, loss of function of certain catalase and peroxidase enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism. In a study conducted to further elucidate ciclopirox's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport [2]. It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase [1]. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur. Initial results show similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties [3].

Clinical Trial
Molecular Weight

207.27

Formula

C₁₂H₁₇NO₂

CAS No.

29342-05-0

SMILES

CC(C=C(C1CCCCC1)N2O)=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (482.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8246 mL 24.1231 mL 48.2462 mL
5 mM 0.9649 mL 4.8246 mL 9.6493 mL
10 mM 0.4825 mL 2.4123 mL 4.8246 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CiclopiroxHOE296bFungalFerroptosisAutophagyInhibitorinhibitorinhibit

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