2. TGF-beta/Smad
  3. TGF-β Receptor
  4. KRFK TFA

KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

KRFK TFA Chemical Structure

KRFK TFA Chemical Structure

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5 mg USD 32 In-stock
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25 mg USD 85 In-stock
50 mg USD 138 In-stock
100 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of KRFK TFA:

KRFK TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KRFK TFA

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Description

KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach[1].

IC50 & Target

TGF-β[1]
In Vitro

KRFK TFA (50 μM; 24 h) activates the secretion of TGF-β and reduces the expression of DC maturation markers in tsp-1 deficient bone marrow-derived dendritic cells (BMDCs) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRFK TFA Related Antibodies
In Vivo

KRFK TFA (5 μg/5 μL/eyes; single dose) significantly prevents the development of chronic ocular surface inflammation in TSP-1-/- mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

577.73 (free base)

Formula

C27H47N9O5.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Lys-Arg-Phe-Lys
Sequence Shortening

KRFK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References
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KRFK TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRFKTGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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