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  4. Prostaglandin E3

Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity.

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Prostaglandin E3 Chemical Structure

Prostaglandin E3 Chemical Structure

CAS No. : 802-31-3

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Other Forms of Prostaglandin E3:

Prostaglandin E3 Related Antibodies

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Description

Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity[1].

In Vitro

Prostaglandin E3 (1-10000 nM) suppresses M1 and induces M2a marker expression in polarized macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prostaglandin E3 Related Antibodies
In Vivo

Prostaglandin E3 (1 µmol/L; i.p.) modulates macrophage polarization towards an anti-inflammatory function in LPS (HY-D1056) (5 mg/kg)-induces acute inflammation model[1].
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 weeks, Nude mice (BABL/c) (PC3 xenograft model)[1]
Dosage: 1 µmol/L for 50 µL
Administration: Injected next to the tumour, every 3 days for 4 weeks
Result: Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.
Animal Model: 6-8-week-old C57BL6/J mice[1]
Dosage: LPS+ PGE3 (5 mg/kg + 1 µmol/L)
Administration: I.p.; once
Result: Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.
Molecular Weight

350.45

Formula

C20H30O5
CAS No.
SMILES

CC/C=C\C[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Prostaglandin E3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prostaglandin E3802-31-3Prostaglandin E 3Prostaglandin E-3Othersmacrophageanti-inflammatoryanti-tumorM2aInhibitorinhibitorinhibit

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