Prostaglandin E3
Based on 1 Customer Validation
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 98.4%
- CAS No.: 802-31-3
- Formula: C20H30O5
- Molecular Weight:350.45
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Prostaglandin E3 (1-10000 nM) suppresses M1 and induces M2a marker expression in polarized macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) shows anti-tumor activity by regulates macrophage polarization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5 weeks, Nude mice (BABL/c) (PC3 xenograft model)[1]
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Dosage:1 µmol/L for 50 µL
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Administration:Injected next to the tumour, every 3 days for 4 weeks
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Result:Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.
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Animal Model:6-8-week-old C57BL6/J mice[1]
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Dosage:LPS+ PGE3 (5 mg/kg + 1 µmol/L)
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Administration:I.p.; once
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Result:Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.
Chemical Information
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CAS No. 802-31-3
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Appearance Liquid
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Molecular Weight 350.45
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Formula C20H30O5
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Color Colorless to light yellow
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SMILES
CC/C=C\C[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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