Cat. No.: HY-B0645

Prednisolone disodium phosphate

(Synonyms: Prednisolone 21-phosphate disodium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Prednisolone disodium phosphate can be rapidly and completely hydrolyzed to Prednisolone in the plasma.

For research use only. We do not sell to patients.

Purity: 99.50%
CAS No.: 125-02-0
Formula: C₂₁H₂₇Na₂O₈P
Molecular Weight:484.39

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Prednisolone disodium phosphate Chemical Structure

CAS No.: 125-02-0

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
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Biological Activity

Description

In Vivo

Pharmacokinetic parameters of Prednisolone Penetration/Formation from Prednisolone disodium phosphate (NZW rabbits were administered to the right eye via 1 drop every five minutes up to 30 minutes^[4]

Dose	AUC(0-6 hours) (μg-hr/ml)	Tmax (hours)	Cmax (μg/ml)
1% solution	3.722²	1.0	1.503³

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 125-02-0
Appearance Solid
Molecular Weight 484.39
Formula C₂₁H₂₇Na₂O₈P
Color White to off-white
SMILES

C[C@@]1([C@@]2(O)C(COP(O[Na])(O[Na])=O)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C1
Synonyms

Prednisolone 21-phosphate disodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

J Biomater Appl

Steroid-loaded reconstituted high-density lipoprotein nanocarrier: A new treatment for systemic lupus erythematosus. [Abstract]

2023 Apr;37(9):1542-1554. PMID: 36869874

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (103.22 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0645 mL

10.3223 mL

20.6445 mL

5 mM

0.4129 mL

2.0645 mL

4.1289 mL

10 mM

0.2064 mL

1.0322 mL

2.0645 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (206.45 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [Content Brief]

[2]. http://en.wikipedia.org/wiki/Prednisolone

[3]. Mooren FC, et al. Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers. Pharm Res. 1998 Jan;15(1):58-65. [Content Brief]

[4]. Musson DG, et al. Comparative corneal penetration of prednisolone sodium phosphate and prednisolone acetate in NZW rabbits. J Ocul Pharmacol. 1991 Summer;7(2):175-82. [Content Brief]

[5]. Boudinot FD, et al. Dose-dependent pharmacokinetics of prednisolone in normal and adrenalectomized rats. J Pharmacokinet Biopharm. 1986 Oct;14(5):453-67. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.0645 mL	10.3223 mL	20.6445 mL	51.6113 mL
	5 mM	0.4129 mL	2.0645 mL	4.1289 mL	10.3223 mL
	10 mM	0.2064 mL	1.0322 mL	2.0645 mL	5.1611 mL
	15 mM	0.1376 mL	0.6882 mL	1.3763 mL	3.4408 mL
	20 mM	0.1032 mL	0.5161 mL	1.0322 mL	2.5806 mL
	25 mM	0.0826 mL	0.4129 mL	0.8258 mL	2.0645 mL
	30 mM	0.0688 mL	0.3441 mL	0.6882 mL	1.7204 mL
	40 mM	0.0516 mL	0.2581 mL	0.5161 mL	1.2903 mL
	50 mM	0.0413 mL	0.2064 mL	0.4129 mL	1.0322 mL
	60 mM	0.0344 mL	0.1720 mL	0.3441 mL	0.8602 mL
	80 mM	0.0258 mL	0.1290 mL	0.2581 mL	0.6451 mL
	100 mM	0.0206 mL	0.1032 mL	0.2064 mL	0.5161 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Prednisolone disodium phosphate

1 Cited Publications

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Prednisolone disodium phosphate

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Publications Citing Use of MedChemExpress (MCE) Prednisolone disodium phosphate

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Prednisolone disodium phosphate

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Covalent Screening Library

Endocrinology Compound Library

Anti-COVID-19 Compound Library

FDA Approved & Pharmacopeial Drug Library

Nuclear Receptor Compound Library

Pain-Related Compound Library

Off-patent Drug Library

MCE Bioactive Compound Library

Covalent Screening Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Prednisolone disodium phosphate

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Prednisolone disodium phosphate Related Classifications

HY-B0645 Related Classifications