1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Amcinonide

Amcinonide (Synonyms: CL-34699)

Cat. No.: HY-B1197 Purity: 99.61%
Handling Instructions

Amcinonide inhibit NO release from activated microglia with IC50 3.38 nM.

For research use only. We do not sell to patients.

Amcinonide Chemical Structure

Amcinonide Chemical Structure

CAS No. : 51022-69-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Amcinonide inhibit NO release from activated microglia with IC50 3.38 nM. Amcinonide has affinity for the glucocorticoid receptor. IC50 value: 3.38 nM [1] Target: NO release in vitro: Simultaneous immunofluorescent staining for T6 and Ia antigenicity within human epidermis of Amcinonide treated skin detected reduced numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. [2] in vivo: Amcinonide is an anti-inflammatory agent, elicites whitening of a few hairs in both pheomelanic and eumelanic mice. Amcinonide brings about a marked reduction in the numbers of DOPA-positive epidermal melanocytes inhabiting the tails of eumelanic or pheomelanic mice. Amcinonide exertes a deleterious influence on the structure and function of tail epidermis. [3]

Molecular Weight

502.57

Formula

C₂₈H₃₅FO₇

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (497.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9898 mL 9.9489 mL 19.8977 mL
5 mM 0.3980 mL 1.9898 mL 3.9795 mL
10 mM 0.1990 mL 0.9949 mL 1.9898 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.61%

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Product Name:
Amcinonide
Cat. No.:
HY-B1197
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