1. Neuronal Signaling
  2. Amyloid-β
  3. PQM130

PQM130 

Cat. No.: HY-128346
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PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development.

For research use only. We do not sell to patients.

PQM130 Chemical Structure

PQM130 Chemical Structure

CAS No. : 2089415-51-8

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Description

PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development[1].

In Vivo

PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) [1].

Animal Model: Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) [1].
Dosage: 0.5 and 1.0 mg/kg.
Administration: IP injection daily for 10 days.
Result: Ameliorated Aβ1-42O-induced cognitive deficits in mice.
Prevented Aβ1-42O-induced neuronal death in mice.
Antagonized Aβ1-42O-Induced Oxidative Stress in Mice.
Regulated GSK3β and ERK1/2 protein expressions in mice.
Reduced Aβ1-42O-induced astrocytic activation in mice.
Molecular Weight

381.46

Formula

C₂₃H₂₇NO₄

CAS No.

2089415-51-8

SMILES

O=C(OCC1CCN(CC2=CC=CC=C2)CC1)/C=C/C3=CC=C(O)C(OC)=C3

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