1. Immunology/Inflammation
  2. NO Synthase
  3. Ciwujianoside C3

Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory.

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Ciwujianoside C3 Chemical Structure

Ciwujianoside C3 Chemical Structure

CAS No. : 114906-74-0

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Based on 1 publication(s) in Google Scholar

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Description

Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory[1][2].

In Vitro

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM and 40 µM
Incubation Time: 24 hours
Result: Has no effect on cell cytotoxicity and inhibits NO production

Western Blot Analysis[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM and 40 µM
Incubation Time: 24 hours
Result: Decreases p-ERK and p-JNK expression.

RT-PCR[1]

Cell Line: RAW 264.7 cells
Concentration: 10 µM, 20 µM and 40 µM
Incubation Time: 24 hours
Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner.
In Vivo
Animal Model: Mice[1]
Dosage: 0.5 mg/kg
Administration: Oral administration; 0.5 mg/kg/day; 17 days
Result: Reinforced object recognition memory.
Molecular Weight

1059.24

Formula

C53H86O21

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@@H](O[C@@]1([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O1)O)O)[C@H](O)[C@H]2O)O[C@H]2OC[C@H]([C@@H](O)[C@H](O)[C@H]3O)O[C@H]3OC([C@]45[C@](CC(C)(C)CC5)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@@H](O[C@@]8([H])[C@@H]([C@H]([C@@H](O)CO8)O)O)CC7)C)([H])CC9)C)([H])[C@]9(C)[C@]6(C)CC4)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

References
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Ciwujianoside C3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ciwujianoside C3
Cat. No.:
HY-N4134
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