2. Apoptosis
  3. TNF Receptor
  4. Epobis

Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties.

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Epobis Chemical Structure

Epobis Chemical Structure

CAS No. : 915091-83-7

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Epobis Related Antibodies

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Description

Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties[1].

In Vitro

Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33 μM[1].
Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Epobis Related Antibodies

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 0-8.82 μM
Incubation Time: 24 hours
Result: Had a significantly higher viability of 64% in a concentration of 8.4 μM, whereas the highest viability (68%) in a concentration of 2.7 μM.
In Vivo

Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB)[1].
Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model[1].
Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had detectable already 15 min after administration and remained detectable in the blood for at least 24 h.
Animal Model: Wistar rats with multiple sclerosis model (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
Animal Model: Old (>18 month) rats and in rats experiencing early stage AD[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had significantly lower than that of vehicle-treated animals.
Molecular Weight

2195.44

Formula

C100H151N27O29
CAS No.
Sequence Shortening

NENITVPDTKVNFYAWKR
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Epobis Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epobis915091-83-7TNF ReceptorTumor Necrosis Factor ReceptorTNFRdendrimeric peptideerythropoietinneuritogenesisanti-inflammatoryblood-brain barriermemory enhancingInhibitorinhibitorinhibit

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