EA-230

Cat. No.: HY-106279: FAQs
Data Sheet Handling Instructions

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EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis.

For research use only. We do not sell to patients.

EA-230 Chemical Structure

CAS No. : 503844-09-5

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Description

EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis^[1].

In Vivo

EA-230 (30-50 mg/kg; i.p.; twice daily for four consecutive days) improves survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl/6 mice, ischemia reperfusion injury model^[1]
Dosage:	20, 30, 40 or 50 mg/kg
Administration:	Intraperitoneal injection, twice daily for four consecutive days
Result:	Improved survival markedly. With doses between 30–50 mg/kg survival reached 56–62%, the low dose treatment with 20 mg/kg did not have a beneficial effect. Significantly increased renal blood flow (RBF), attenuated CTGF up-regulation, enhanced tubular epithelial cell regeneration and attenuated TGF-beta activation.

Clinical Trial

Molecular Weight

373.40

Formula

C₁₅H₂₇N₅O₆

CAS No.

503844-09-5

Sequence Shortening

AQGV

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gueler F, et al. A novel therapy to attenuate acute kidney injury and ischemic allograft damage after allogenic kidney transplantation in mice. PLoS One. 2015 Jan 24;10(1):e0115709. [Content Brief]

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EA-230503844-09-5EA230EA 230Othersoligopeptidebeta-hCGbeta-human chorionic gonadotropinanti-inflammatorysepsisischemia reperfusion injury modelIRIAQGVInhibitorinhibitorinhibit

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