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Sodium gualenate (Synonyms: Guaiazulenesulfonate sodium)

Cat. No.: HY-B2191 Purity: ≥98.0%
Handling Instructions

Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

For research use only. We do not sell to patients.

Sodium gualenate Chemical Structure

Sodium gualenate Chemical Structure

CAS No. : 6223-35-4

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Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

In Vitro

Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water[1]. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.35

Formula

C15H17NaO3S

CAS No.
SMILES

O=S(C1=C2C(C)=CC=C(C(C)C)C=C2C(C)=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (99.88 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3294 mL 16.6472 mL 33.2945 mL
5 mM 0.6659 mL 3.3294 mL 6.6589 mL
10 mM 0.3329 mL 1.6647 mL 3.3294 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Sodium gualenate
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HY-B2191
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