1. Flavonoids
  2. Farrerol

Farrerol 

Cat. No.: HY-N0344
Handling Instructions

Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects.

For research use only. We do not sell to patients.

Farrerol Chemical Structure

Farrerol Chemical Structure

CAS No. : 24211-30-1

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Description

Farrerol is a bioactive constituent of Rhododendron, with broad activities such as anti-oxidative, anti-inflammatory, anti-tumor, neuroprotective and hepatoprotective effects[1][2][3][4][5][6].

In Vitro

Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation[1].
Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line[2].
Farrerol inhibits angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway[3].
Farrerol overcomes the invasiveness of lung squamous cell carcinoma cells by regulating the expression of inducers of epithelial mesenchymal transition[4].
Farrerol ameliorates acetaminophen-induced hepatotoxicity via activation of Nrf2 and autophagy[6].

In Vivo

Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-κB signaling pathways[5].

Molecular Weight

300.31

Formula

C₁₇H₁₆O₅

CAS No.

24211-30-1

SMILES

O=C1C[[email protected]@H](C2=CC=C(O)C=C2)OC3=C(C)C(O)=C(C)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FarrerolOthersInhibitorinhibitorinhibit

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